基于模板策略的DNA序列设计

DNA sequence design based on template strategy.

作者信息

Liu Wenbin, Wang Shudong, Gao Lin, Zhang Fengyue, Xu Jin

机构信息

Department of Control Science and Engineering, Huazhong University of Science and Technology, Wuhan City 430074, China.

出版信息

J Chem Inf Comput Sci. 2003 Nov-Dec;43(6):2014-8. doi: 10.1021/ci025645s.

DOI:10.1021/ci025645s

PMID:14632452

Abstract

In DNA based computation and DNA nanotechnology, the design of proper DNA sequences has turned out to be an elementary problem. This paper takes a further look at the template strategy proposed in work by Frutos, A. G. et al. (Nucleic Acids Res. 1997, 25, 4748-4757). The H-measure proposed by Garzon et al. (Proceedings of the Second Annual Genetic Programming Conference, 1997; pp 472-487) is combined in this strategy to optimize the template and map sets obtained. Finally we describe a constructing method that can still produce more sequences by the results obtained in this paper.

摘要

在基于DNA的计算和DNA纳米技术中，设计合适的DNA序列已成为一个基本问题。本文进一步探讨了弗鲁托斯等人（《核酸研究》，1997年，第25卷，4748 - 4757页）工作中提出的模板策略。加尔松等人（《第二届年度遗传编程会议论文集》，1997年；第472 - 487页）提出的H度量被结合到该策略中，以优化获得的模板和映射集。最后，我们描述了一种构建方法，该方法仍可根据本文获得的结果生成更多序列。