Hu Xuejiao, Forster Jameson, Damjanov Ivan
Department of Pathology, The University of Kansas School of Medicine, Kansas City, Kan 66160-7410, USA.
Arch Pathol Lab Med. 2003 Dec;127(12):1606-8. doi: 10.5858/2003-127-1606-PMGSTO.
We report the case of a malignant, primary, hepatic gastrointestinal stromal tumor (GIST) that was resected from the liver of a 79-year-old woman. To our knowledge, this is the first primary, hepatic GIST on record. The tumor expressed CD117 (c-Kit protein) and vimentin and had the ultrastructural features of GISTs. Sixteen months after partial hepatectomy and resection of the tumor, a hilar lymph node metastasis was found. The metastatic tumor had the same morphologic features as the primary tumor, but in addition it contained numerous multinucleated giant cells. This case shows that GIST can occur as a primary liver tumor, and accordingly, we point out that not all hepatic tumors with a GIST phenotype should be automatically considered to be metastases from a primary gastrointestinal site.
我们报告了一例从一名79岁女性肝脏切除的恶性原发性肝胃肠间质瘤（GIST）病例。据我们所知，这是有记录以来首例原发性肝GIST。肿瘤表达CD117（c-Kit蛋白）和波形蛋白，具有GIST的超微结构特征。在部分肝切除和肿瘤切除术后16个月，发现肝门淋巴结转移。转移瘤具有与原发肿瘤相同的形态学特征，但此外还含有大量多核巨细胞。该病例表明GIST可作为原发性肝肿瘤发生，因此，我们指出并非所有具有GIST表型的肝肿瘤都应自动被认为是来自原发性胃肠道部位的转移瘤。
