Padilla Catalina, Saez Amparo, Vidal August, Garcia Lluis, Tolosa Filomena, Andreu F Javier, Combalia Neus
Department of Pathology, Corporació Parc Taulí, Sabadell, Barcelona, Spain.
Diagn Cytopathol. 2002 Nov;27(5):298-302. doi: 10.1002/dc.10191.
Gastrointestinal stromal tumor (GIST) is the designation for a major subset of gastrointestinal mesenchymal tumors that histologically, immunocytochemically, and genetically differ from leiomyomas, leiomyosarcomas, and schwannomas. GISTs derive from the interstitial cells of Cajal and, in addition to variable expression of smooth muscle and neural markers, they characteristically express CD34 and CD117. The cytological appearance, including immunocytochemical and mutational analysis of c-kit gene in primary GIST has been well described. To our knowledge, only two cases of metastatic GIST diagnosed by fine-needle aspiration (FNA) have been reported. We illustrate three cases of metastatic GIST in the liver. Two cases had no prior history of gastrointestinal tumor and the third case had a 4-yr previous history of duodenal tumor. Consistent immunocytochemistry and ultrastructual studies supported the diagnosis of GIST. We emphasize that in the appropriate clinical and radiological setting, a confident diagnosis of GIST can be established by FNA of metastatic lesions.
胃肠道间质瘤（GIST）是胃肠道间叶性肿瘤的一个主要亚型，在组织学、免疫细胞化学和遗传学方面与平滑肌瘤、平滑肌肉瘤及神经鞘瘤不同。GIST起源于 Cajal 间质细胞，除了平滑肌和神经标志物的可变表达外，它们还特征性地表达 CD34 和 CD117。原发性 GIST 的细胞学表现，包括免疫细胞化学和 c-kit 基因的突变分析，已有详细描述。据我们所知，仅有两例经细针穿刺抽吸（FNA）诊断为转移性 GIST 的病例报道。我们展示了三例肝脏转移性 GIST 病例。两例既往无胃肠道肿瘤病史，第三例有 4 年十二指肠肿瘤病史。一致的免疫细胞化学和超微结构研究支持 GIST 的诊断。我们强调，在合适的临床和影像学背景下，通过对转移性病变进行 FNA 可以确诊 GIST。
