Coyne K S, Zhou Z, Bhattacharyya S K, Thompson C L, Dhawan R, Versi E
MEDTAP International, Bethesda, MD 20814, USA.
BJU Int. 2003 Dec;92(9):948-54. doi: 10.1111/j.1464-410x.2003.04527.x.
To evaluate the prevalence of nocturia and its effects, with and without concomitant overactive bladder (OAB, i.e. urgency, frequency, urge incontinence and nocturia), on health-related quality of life (HRQoL) and sleep.
A national survey was conducted in the USA to assess the prevalence of OAB and nocturia. A nested case-control study was conducted among respondents with OAB symptoms and age- and gender-matched controls, with participants completing a series of questionnaires on HRQoL (OAB-q, Short Form-36, and Medical Outcomes Study (MOS) sleep scale). Descriptive analyses, t-tests, analysis of variance with post hoc comparisons and multivariate regressions were used to analyse the data.
In all, 5204 people participated in the survey, with 919 in the nested case-control study. The sample population had a mean age of 45.8 years, was 52.6% female and 80% Caucasian. In the community sample, 31% reported > 1 void/night and 14.2% reported > 2 voids/night. The prevalence of nocturia increased with age, with no gender differences. For OAB cases, 66.8% reported > 1 void/night and 42.2% reported > 2. In the case-control cohort there were significant HRQoL differences (P < 0.01), with increasing episodes of nocturia in all OAB-q subscales except social interaction. The amount of sleep per night was significantly correlated with the sleep, concern and social interaction OABq subscale scores. The number of nocturia episodes/night was also significantly (P = 0.02) associated with the number of hours of sleep/night.
Nocturia is widely prevalent and increases with age, affecting men and women equally. Incremental increases in the number of voids/night have further negative effects on sleep, symptom bother, and HRQoL.
评估夜尿症的患病率及其对健康相关生活质量（HRQoL）和睡眠的影响，包括伴有和不伴有膀胱过度活动症（OAB，即尿急、尿频、急迫性尿失禁和夜尿症）的情况。
在美国进行了一项全国性调查，以评估OAB和夜尿症的患病率。在有OAB症状的受访者及其年龄和性别匹配的对照组中进行了一项巢式病例对照研究，参与者完成了一系列关于HRQoL的问卷（OAB-q、简短健康调查问卷-36和医学结局研究（MOS）睡眠量表）。采用描述性分析、t检验、事后比较的方差分析和多元回归分析数据。
共有5204人参与了调查，其中919人参与了巢式病例对照研究。样本人群的平均年龄为45.8岁，女性占52.6%，白种人占80%。在社区样本中，31%的人报告每晚排尿次数>1次，14.2%的人报告每晚排尿次数>2次。夜尿症的患病率随年龄增长而增加，无性别差异。对于OAB患者，66.8%的人报告每晚排尿次数>1次，42.2%的人报告每晚排尿次数>2次。在病例对照队列中，HRQoL存在显著差异（P<0.01），除社交互动外，所有OAB-q子量表中的夜尿症发作次数均增加。每晚的睡眠时间与睡眠、担忧和社交互动OABq子量表得分显著相关。每晚夜尿症发作次数也与每晚睡眠时间显著相关（P = 0.02）。
夜尿症普遍存在且随年龄增长而增加，对男性和女性的影响相同。每晚排尿次数的增加对睡眠、症状困扰和HRQoL有进一步的负面影响。
