Nadol J B, Xu W Z
Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts.
Ann Otol Rhinol Laryngol. 1992 Dec;101(12):988-93. doi: 10.1177/000348949210101205.
Although the parameters that are most important for postoperative speech perception in cochlear implantation have not been identified, it is assumed that the numbers of remaining cochlear neurons and spiral ganglion cells in the implanted deaf ears are critical. In this study, we evaluated the correlation of the maximum diameter of the cochlear and vestibular nerve trunks with the number of spiral ganglion cells in horizontal sections of the temporal bone of 42 patients who were profoundly deaf during life, and in 5 patients with normal hearing. The maximum diameters of the cochlear, vestibular, and eighth cranial nerves were significantly smaller in the deaf population as compared to normal-hearing controls. In addition, the counts of the remaining spiral ganglion cells were significantly correlated with the maximum diameter of the cochlear (p = .0006), vestibular (p = .001), and eighth cranial nerves (p = .0003). The regression equation estimated that 25% of the variance of the spiral ganglion cell count was predicted by the maximum diameter of the eighth nerve. Although the results of this study suggest that preoperative radiographic imaging of the diameter of the eighth nerve may be helpful in predicting the residual spiral ganglion cell count, the wide variability of diameters of the eighth nerve in hearing and deaf subjects militates against this theoretic usefulness.
尽管人工耳蜗植入术后言语感知最重要的参数尚未明确，但一般认为植入侧耳聋耳中残留的耳蜗神经元和螺旋神经节细胞数量至关重要。在本研究中，我们评估了42例生前重度耳聋患者及5例听力正常患者颞骨水平切片中，耳蜗和前庭神经干的最大直径与螺旋神经节细胞数量之间的相关性。与听力正常的对照组相比，耳聋人群的耳蜗、前庭和第八对脑神经的最大直径明显更小。此外，残留螺旋神经节细胞的计数与耳蜗（p = 0.0006）、前庭（p = 0.001）和第八对脑神经（p = 0.0003）的最大直径显著相关。回归方程估计，第八对神经最大直径可预测螺旋神经节细胞计数25%的方差。尽管本研究结果表明，术前对第八对神经直径进行影像学检查可能有助于预测残留螺旋神经节细胞计数，但听力正常和耳聋受试者中第八对神经直径的广泛变异性削弱了这一理论上的实用性。
