Chiong C M, Xu W Z, Glynn R J, Nadol J B
Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts.
Ann Otol Rhinol Laryngol. 1993 Jun;102(6):425-8. doi: 10.1177/000348949310200603.
The electrically evoked auditory brain stem response in some cochlear implant patients may be confounded by evoked potentials generated by vestibular neurons. The magnitude of this contribution to the response from the vestibular system is unknown, in part because the survival of cells within Scarpa's ganglion in profoundly deaf humans is unknown. Therefore, we undertook a quantitative study of Scarpa's ganglion in 48 deaf subjects who in life would have been candidates for cochlear implantation and in 5 subjects with normal hearing. The numbers of residual cells in both Scarpa's ganglion and the spiral ganglion in deaf subjects were significantly less than in individuals with normal hearing. Bivariate analysis demonstrated a highly significant positive correlation between cell counts of Scarpa's ganglion and the spiral ganglion. The durations of hearing loss and of profound deafness were negatively correlated with Scarpa's ganglion cell counts. However, in contrast to spiral ganglion cell survival, the cause of profound deafness did not predict the number of Scarpa's ganglion cells. Multiple linear regression analysis using a variety of clinical parameters demonstrated that the best predictor of the number of Scarpa's ganglion cells in profoundly deaf humans was the number of remaining spiral ganglion cells.
一些人工耳蜗植入患者的电诱发听觉脑干反应可能会被前庭神经元产生的诱发电位所混淆。前庭系统对该反应的贡献程度尚不清楚，部分原因是极重度聋患者斯卡帕神经节内细胞的存活情况未知。因此，我们对48名生前曾是人工耳蜗植入候选者的聋人受试者以及5名听力正常的受试者的斯卡帕神经节进行了定量研究。聋人受试者斯卡帕神经节和螺旋神经节中的残余细胞数量显著少于听力正常者。双变量分析显示，斯卡帕神经节和螺旋神经节的细胞计数之间存在高度显著的正相关。听力损失和极重度聋的持续时间与斯卡帕神经节细胞计数呈负相关。然而，与螺旋神经节细胞存活情况不同的是，极重度聋的病因并不能预测斯卡帕神经节细胞的数量。使用多种临床参数进行的多元线性回归分析表明，极重度聋患者斯卡帕神经节细胞数量的最佳预测指标是剩余螺旋神经节细胞的数量。
