Chen Paul Chih-Hsueh, Chang Yen-Hwa, Yen Chueh-Chuan, Pan Chin-Chen, Chiang Hung
Department of Pathology, Division of Medical Oncology, Veterans General Hospital and Yang-Ming University, Taipei, Taiwan.
Int J Urol. 2003 Dec;10(12):657-60. doi: 10.1046/j.1442-2042.2003.00713.x.
Primary renal synovial sarcoma is an uncommon and perhaps under-diagnosed disease. We report a case of renal tumor in a 19-year-old man. Clinically, the tumor mimicked renal cell carcinoma with renal vein, inferior vena cava and right atrium invasion. Histologically, the tumor consisted of monophasic, high-grade, spindle cell components. The diagnosis was validated by fluorescence in situ hybridization and reverse transcription-polymerase chain reaction, which demonstrated SYT-SSX translocation: a characteristic cytogenetic finding for synovial sarcoma. Our case shows that synovial sarcoma should be considered in the differential diagnosis of renal tumors, especially in adolescents and young adults. Proper molecular analysis should be undertaken to attain a definitive diagnosis.
原发性肾滑膜肉瘤是一种罕见且可能诊断不足的疾病。我们报告一例19岁男性的肾肿瘤病例。临床上，该肿瘤类似肾细胞癌，侵犯肾静脉、下腔静脉和右心房。组织学上，肿瘤由单相、高级别、梭形细胞成分组成。荧光原位杂交和逆转录聚合酶链反应验证了诊断，结果显示SYT-SSX易位：这是滑膜肉瘤的特征性细胞遗传学发现。我们的病例表明，在肾肿瘤的鉴别诊断中应考虑滑膜肉瘤，尤其是在青少年和青年成人中。应进行适当的分子分析以获得明确诊断。
