Zadeh Gelareh, Guha Abhijit
Arthur & Sonia Labatts Brain Tumor Center, Hospital for Sick Children's Research Institute, University of Toronto, Toronto, Ontario, Canada.
Neurosurgery. 2003 Dec;53(6):1362-74; discussion 1374-6. doi: 10.1227/01.neu.0000093425.98136.31.
Angiogenesis is a crucial requirement for embryonal development and new vessel formation during adult life. Various disease processes such as cancer, ischemia, vascular malformations, and inflammatory processes also depend on pathological angiogenesis. A better understanding of the complex and coordinated interactions among various angiogenic pathways involved in pathological angiogenesis is necessary to improve our therapeutic approaches to the various disease processes observed in the central nervous system. This review summarizes the current understanding of the role of principal angiogenic factors relevant to neurosurgical abnormalities.
血管生成是胚胎发育和成年期新血管形成的关键条件。各种疾病过程，如癌症、缺血、血管畸形和炎症过程，也依赖于病理性血管生成。更好地理解病理性血管生成中涉及的各种血管生成途径之间复杂且协同的相互作用，对于改进我们针对中枢神经系统中观察到的各种疾病过程的治疗方法是必要的。本综述总结了目前对与神经外科异常相关的主要血管生成因子作用的理解。
