Huang Zhi, Bao Shi-Deng
Cell Biology Research Lab, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian Province, China.
World J Gastroenterol. 2004 Feb 15;10(4):463-70. doi: 10.3748/wjg.v10.i4.463.
Tumor growth without size restriction depends on vascular supply. The ability of tumor to induce new blood-vessel formation has been a major focus of cancer research over the past decade. It is now known that members of the vascular endothelial growth factor and angiopoietin families, mainly secreted by tumor cells, induce tumor angiogenesis, whereas other endogenous angiogenic inhibitors, including thrombospondin-1 and angiostatin, keep tumor in dormancy. Experimental and clinical evidence has suggested that the process of tumor metastasis depends on angiogenesis or lymphangiogenesis. This article summarizes the recent research progress for some basic pro- or anti-angiogenic factors in tumor angiogenesis.
不受大小限制的肿瘤生长依赖于血管供应。在过去十年中，肿瘤诱导新血管形成的能力一直是癌症研究的主要焦点。现在已知，主要由肿瘤细胞分泌的血管内皮生长因子和血管生成素家族成员可诱导肿瘤血管生成，而其他内源性血管生成抑制剂，包括血小板反应蛋白-1和血管抑素，则使肿瘤处于休眠状态。实验和临床证据表明，肿瘤转移过程依赖于血管生成或淋巴管生成。本文总结了肿瘤血管生成中一些基本的促血管生成或抗血管生成因子的最新研究进展。
