Yasuda Yoshikazu, Takeda Akiko, Fukuda Satoru, Suzuki Hisato, Ishimoto Masayuki, Mori Yoshiteru, Eguchi Hirotake, Saitoh Ritsuko, Fujihara Hideyoshi, Honda Kazumasa, Higuchi Takashi
Departments of *Anesthesiology & Reanimatology and †Physiology, Fukui Medical University, Fukui, Japan.
Anesth Analg. 2003 Dec;97(6):1663-1666. doi: 10.1213/01.ANE.0000089964.85834.EF.
We studied the effects of intracerebroventricular injection of the novel neuropeptide orexin A on electroencephalogram (EEG) and autonomic nervous system activity in rats under isoflurane anesthesia. The administration of orexin A changed burst suppression patterns to arousal patterns on the EEG at 1.0 minimum alveolar anesthetic concentration (MAC) isoflurane and decreased the burst suppression ratio at 1.5 MAC isoflurane. However, orexin A did not influence the heart rate or mean arterial blood pressure at either isoflurane concentration. These findings demonstrated that orexin A elicited anesthetic arousal under isoflurane anesthesia in terms of EEG pattern without sympathetic cardiovascular activation in the rat.
The novel neuropeptides orexins induce arousal associated with activation of the sympathetic nervous system in conscious rats. It is not known whether orexins affect the electroencephalogram (EEG), autonomic nerve activity, or both under anesthesia. Orexin A induced EEG arousal without sympathetic cardiovascular activation in the isoflurane-anesthetized rat. Orexin A might influence the depth of anesthesia.
我们研究了在异氟烷麻醉下，向大鼠脑室内注射新型神经肽食欲素A对脑电图（EEG）和自主神经系统活动的影响。在1.0最低肺泡麻醉浓度（MAC）异氟烷时，注射食欲素A可使脑电图上的爆发抑制模式转变为觉醒模式，并在1.5 MAC异氟烷时降低爆发抑制率。然而，在任一异氟烷浓度下，食欲素A均不影响心率或平均动脉血压。这些发现表明，在大鼠中，食欲素A在异氟烷麻醉下可根据脑电图模式引发麻醉觉醒，而无交感心血管激活。
新型神经肽食欲素在清醒大鼠中可诱导与交感神经系统激活相关的觉醒。目前尚不清楚食欲素在麻醉状态下是否会影响脑电图（EEG）、自主神经活动或两者。在异氟烷麻醉的大鼠中，食欲素A可诱导脑电图觉醒，而无交感心血管激活。食欲素A可能会影响麻醉深度。
