Winter Manon J, Nagtegaal Iris D, van Krieken J Han J M, Litvinov Sergey V
Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Am J Pathol. 2003 Dec;163(6):2139-48. doi: 10.1016/S0002-9440(10)63570-5.
Cell adhesion receptors (CAMs) are actively involved in regulating various cell processes, including growth, differentiation, and cell death. Therefore, CAMs represent a large group of morphoregulating molecules, mediating cross-talk between cells and of cells with their environment. From this perspective, CAMs do contribute to cells and tissue organization, and in diseased tissue, to the disease development and biological characteristics. Therefore, observed changes in expression patterns of adhesion molecules may contribute to establish a diagnosis. A distinct shift in expression patterns in neoplastic epithelium has been described, for example for cadherins, integrins, and CD44. A relatively novel cell CAM, Ep-CAM, was first reported to be a pan-carcinoma antigen, although it is rather a marker of epithelial lineage. Several antibodies directed to Ep-CAM have been generated, and many epithelial tissues and their neoplastic appendages have been studied. This article outlines the results of these studies. Based on the results of these studies, we conclude that Ep-CAM immunohistochemistry can be a useful tool in the diagnosis of disturbed epithelial tissues.
细胞黏附受体（CAMs）积极参与调节各种细胞过程，包括生长、分化和细胞死亡。因此，CAMs代表了一大类形态调节分子，介导细胞之间以及细胞与其环境之间的相互作用。从这个角度来看，CAMs确实有助于细胞和组织的组织，而在患病组织中，则有助于疾病的发展和生物学特性。因此，观察到的黏附分子表达模式的变化可能有助于做出诊断。例如，已经描述了肿瘤上皮中钙黏蛋白、整合素和CD44等表达模式的明显转变。一种相对新颖的细胞CAM，Ep-CAM，最初被报道为一种泛癌抗原，尽管它实际上是上皮谱系的标志物。已经产生了几种针对Ep-CAM的抗体，并且已经研究了许多上皮组织及其肿瘤附属物。本文概述了这些研究的结果。基于这些研究的结果，我们得出结论，Ep-CAM免疫组织化学可以成为诊断上皮组织紊乱的有用工具。
