Price G
Department of Anaesthesia, Victoria Hospital, Kirkcaldy, Fife, Scotland, UK.
Br J Anaesth. 2003 Dec;91(6):909-10. doi: 10.1093/bja/aeg255.
A patient with acute renal failure associated with lactic acidosis as a result of concurrent treatment with metformin is described. Rofecoxib may have been a precipitating factor. The risk of renal failure with the use of traditional NSAIDs is well known. However, what is less well appreciated is the role that the COX 2 inhibitors may play in the development of renal failure which, when it occurs in a patient on metformin, can lead to a potentially disastrous outcome.
本文描述了一名因同时服用二甲双胍而发生急性肾衰竭并伴有乳酸酸中毒的患者。罗非昔布可能是一个诱发因素。使用传统非甾体抗炎药（NSAIDs）导致肾衰竭的风险是众所周知的。然而，人们对COX-2抑制剂在肾衰竭发生过程中可能扮演的角色了解较少，而当肾衰竭发生在服用二甲双胍的患者身上时，可能会导致潜在的灾难性后果。
