Mallick S
Postgrad Med J. 2004 Apr;80(942):239-40. doi: 10.1136/pgmj.2003.011957.
Metformin is a biguanide commonly used in type 2 diabetes and considered to be a safe drug with minimal side effects. Approximately 2% of cases of acute pancreatitis may be caused by drugs, but it is not a known complication of metformin therapy. To date only one case of pancreatitis has been reported in association with metformin, but that was secondary to metformin poisoning (overdose). This is the first reported case of pancreatitis caused by a therapeutic dose of metformin (although in this case renal failure precipitated the metformin toxicity). Severe lactic acidosis is a rare but life threatening complication of metformin, which occurs particularly in patients with renal failure.
二甲双胍是一种常用于2型糖尿病的双胍类药物，被认为是一种副作用极小的安全药物。约2%的急性胰腺炎病例可能由药物引起，但二甲双胍治疗并未被认为会引发这一并发症。迄今为止，仅报告过一例与二甲双胍相关的胰腺炎病例，但该病例继发于二甲双胍中毒（过量服用）。这是首例报告的由治疗剂量的二甲双胍引起的胰腺炎病例（尽管在本病例中，肾衰竭促使了二甲双胍毒性的发生）。严重乳酸酸中毒是二甲双胍罕见但危及生命的并发症，尤其发生于肾衰竭患者。
