Cherpitel Cheryl J, Ye Yu, Bond Jason, Borges Guilherme
Public Health Institute, Alcohol Research Group, Berkeley, California 94709, USA.
Alcohol Clin Exp Res. 2003 Nov;27(11):1805-12. doi: 10.1097/01.ALC.0000095863.78842.F0.
Whereas a substantial literature exists documenting the association of alcohol and injuries, causal associations are less well established.
The relationship of drinking-in-the-event variables with attributing a causal association of alcohol consumption and the injury event was examined by using meta-analysis across 13 emergency room studies from 8 countries included in the Emergency Room Collaborative Alcohol Analysis Project.
Pooled odds ratios for both log-transformed blood alcohol concentration at the time of the emergency room visit and the amount of alcohol consumed in the 6 hr before injury were positively predictive (1.19 and 1.80, respectively) and heterogeneous across studies. Effect size changed little when age and gender were controlled. When stratifying on reporting five or more drinks on an occasion during the last year (5+ yearly drinkers), the amount consumed was positively predictive of reporting a casual association of drinking and injury only for 5+ yearly drinkers. The effect size of feeling drunk at the time of injury, controlling for the amount of alcohol consumed, was positively predictive (2.04) but heterogeneous across studies. Meta-analysis regression found the level to which alcohol is consumed in a detrimental pattern to be a significant predictor of blood alcohol concentration, and of the amount consumed and feeling drunk at the time of injury, on causal attribution, with a lower detrimental pattern level with a larger effect size.
The association of acute use of alcohol on causal attribution may be affected by chronic use to some extent, but this association is negatively affected by the degree to which a society exhibits harmful drinking patterns.
尽管有大量文献记录了酒精与伤害之间的关联,但因果关联尚未完全确立。
通过对来自8个国家的13项急诊室研究进行荟萃分析,这些研究被纳入急诊室酒精联合分析项目,研究饮酒事件变量与酒精消费因果关联及伤害事件归因之间的关系。
急诊室就诊时经对数转换的血液酒精浓度以及受伤前6小时内的酒精摄入量的合并比值比均具有正向预测性(分别为1.19和1.80),且各研究之间存在异质性。在控制年龄和性别后,效应量变化不大。当对过去一年中单次报告饮用五杯或更多酒(每年饮酒量≥5杯者)进行分层时,仅对于每年饮酒量≥5杯者,饮酒量才正向预测报告饮酒与伤害之间的因果关联。在控制酒精摄入量的情况下,受伤时感觉醉酒的效应量具有正向预测性(2.04),但各研究之间存在异质性。荟萃分析回归发现,以有害模式饮酒的程度是血液酒精浓度、饮酒量以及受伤时感觉醉酒对因果归因的显著预测因素,有害模式程度越低,效应量越大。
酒精急性使用与因果归因之间的关联可能在一定程度上受到长期使用的影响,但这种关联会受到社会有害饮酒模式程度的负面影响。