Schlembach Dietmar, Scalera Fortunato, Fischer Tina, Marx Stephen G, Beinder Ernst, Garfield Robert E
Departments of Obstetrics and Gynecology, University of Erlangen-Nuremberg, Erlangen, Germany.
Am J Obstet Gynecol. 2003 Nov;189(5):1418-22. doi: 10.1067/s0002-9378(03)00775-0.
The purpose of this study was to examine neurokinin B levels in serum from preeclamptic and normotensive and to investigate the role of neurokinin B in preeclampsia.
Peripheral and uterine venous blood neurokinin B levels were measured in 14 normotensive and 8 preeclamptic pregnant women by radioimmunoassay.
Neurokinin B levels in normotensive women were 4.91 +/- 2.67 nmol/L in peripheral and 5.59 +/- 2.06 nmol/L in uterine blood. In pregnant women with preeclampsia, neurokinin B levels were 2.79 +/- 1.68 nmol/L and 3.20 +/- 1.55 nmol/L, respectively. Neurokinin B levels were significantly higher in normotensive women (P=.032 in peripheral and P=.006 in uterine blood).
Neurokinin B serum levels were higher in normotensive women. Higher neurokinin B concentrations in normotensive pregnant women may be due to the advanced gestational age and/or the result of a negative interaction of other vasoactive substances. The role of neurokinin B in preeclampsia remains to be determined.
本研究旨在检测子痫前期患者与血压正常孕妇血清中的神经激肽B水平，并探究神经激肽B在子痫前期中的作用。
采用放射免疫分析法测定了14例血压正常孕妇和8例子痫前期孕妇外周血及子宫静脉血中的神经激肽B水平。
血压正常孕妇外周血神经激肽B水平为4.91±2.67 nmol/L，子宫血中为5.59±2.06 nmol/L。子痫前期孕妇的神经激肽B水平分别为2.79±1.68 nmol/L和3.20±1.55 nmol/L。血压正常孕妇的神经激肽B水平显著更高（外周血P = 0.032，子宫血P = 0.006）。
血压正常孕妇血清神经激肽B水平更高。血压正常孕妇中神经激肽B浓度较高可能是由于孕周较大和/或其他血管活性物质负性相互作用的结果。神经激肽B在子痫前期中的作用仍有待确定。
