Zulfikaroglu Ebru, Ugur Mustafa, Taflan Selen, Ugurlu Nil, Atalay Aral, Kalyoncu Senol
Department of Obstetrics and Gynecology, Ankara Dr Zekai Tahir Burak Women Health Teaching and Research Hospital, 06100-Ankara, Turkey.
J Perinat Med. 2007;35(3):200-2. doi: 10.1515/JPM.2007.050.
Neurokinin (NK) B has been recently demonstrated to be secreted by the placenta in preeclampsia suggesting it may modulate pathophysiological events of the disease. The aim of this study was to investigate whether NKB is the circulating factor associated with preeclampsia or not. In 22 preeclamptic and normotensive pregnant women, the peripheral and umbilical cord blood NKB levels were measured by radioimmunoassay. The NKB levels in women with preeclampsia were 0.70 (0.53-0.92) nmol/L in peripheral blood and 1.92 (1.42-2.35) nmol/L in umbilical cord blood. In normotensive pregnant women, NKB levels were 0.43 (0.29-0.61) nmol/L and 0.14 (0.07-0.33), respectively. Significantly higher levels of NKB were measured in preeclamptic women compared with normotensive pregnant women in umbilical cord blood. These results suggest that NKB enters both fetal and maternal circulation and may modulate fetoplacental hemodynamics.
最近有研究表明，神经激肽（NK）B由子痫前期患者的胎盘分泌，提示其可能调节该疾病的病理生理过程。本研究旨在探讨NKB是否为子痫前期相关的循环因子。采用放射免疫分析法测定了22例子痫前期孕妇和血压正常孕妇外周血及脐血中的NKB水平。子痫前期患者外周血NKB水平为0.70（0.53 - 0.92）nmol/L，脐血为1.92（1.42 - 2.35）nmol/L。血压正常孕妇外周血和脐血NKB水平分别为0.43（0.29 - 0.61）nmol/L和0.14（0.07 - 0.33）nmol/L。与血压正常孕妇相比，子痫前期患者脐血中NKB水平显著升高。这些结果表明，NKB可进入胎儿和母体循环，可能调节胎儿胎盘血流动力学。
