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Human cloning: can it be made safe?

作者信息

Rhind Susan M, Taylor Jane E, De Sousa Paul A, King Tim J, McGarry Michelle, Wilmut Ian

机构信息

Department of Veterinary Pathology, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK.

出版信息

Nat Rev Genet. 2003 Nov;4(11):855-64. doi: 10.1038/nrg1205.

DOI:10.1038/nrg1205
PMID:14634633
Abstract

There are continued claims of attempts to clone humans using nuclear transfer, despite the serious problems that have been encountered in cloning other mammals. It is known that epigenetic and genetic mechanisms are involved in clone failure, but we still do not know exactly how. Human reproductive cloning is unethical, but the production of cells from cloned embryos could offer many potential benefits. So, can human cloning be made safe?

摘要

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Cloning by SCNT: Integrating Technical and Biology-Driven Advances.体细胞核移植克隆:整合技术和生物学驱动的进展。
Methods Mol Biol. 2023;2647:1-35. doi: 10.1007/978-1-0716-3064-8_1.
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Mitochondrial DNA Depletion in Granulosa Cell Derived Nuclear Transfer Tissues.颗粒细胞来源的核移植组织中的线粒体DNA耗竭
Front Cell Dev Biol. 2021 May 14;9:664099. doi: 10.3389/fcell.2021.664099. eCollection 2021.
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Screening somatic cell nuclear transfer parameters for generation of transgenic cloned cattle with intragenomic integration of additional gene copies that encode bovine adipocyte-type fatty acid-binding protein (A-FABP).
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Thinking outside the liver: induced pluripotent stem cells for hepatic applications.跳出肝脏思维:诱导多能干细胞在肝脏中的应用。
World J Gastroenterol. 2013 Jun 14;19(22):3385-96. doi: 10.3748/wjg.v19.i22.3385.
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Quantification of leukocyte genomic 5-methylcytosine levels reveals epigenetic plasticity in healthy adult cloned cattle.白细胞基因组5-甲基胞嘧啶水平的定量分析揭示了健康成年克隆牛的表观遗传可塑性。
Cell Reprogram. 2010 Apr;12(2):175-81. doi: 10.1089/cell.2009.0062.
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Advances in reprogramming somatic cells to induced pluripotent stem cells.体细胞重编程为诱导多能干细胞的研究进展。
Stem Cell Rev Rep. 2010 Sep;6(3):367-80. doi: 10.1007/s12015-010-9123-8.
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Active tissue-specific DNA demethylation conferred by somatic cell nuclei in stable heterokaryons.稳定异核体中体细胞核对活性组织特异性DNA去甲基化的赋予作用
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