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老年患者行主动脉瓣置换术时同期进行冠状动脉旁路移植术。一个额外的危险因素?

Concomitant CABG-procedures in elderly patients undergoing aortic valve replacement. An additional risk factor?

作者信息

Litmathe J, Boeken U, Feindt P, Gams E

机构信息

Dept. of Thoracic- and Cardiovascular Surgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, Germany.

出版信息

Z Kardiol. 2003 Nov;92(11):947-52. doi: 10.1007/s00392-003-0994-4.

Abstract

OBJECTIVE

Preoperative coronary angiography in elderly people referred to the hospital for aortic valve replacement (AVR) often shows additional significant stenoses of the coronary arteries (CAD). The benefit of concomitant coronary artery bypass grafting (CABG) in these patients is still discussed controversially. By some authors, an isolated AVR in elderly patients with additional CAD is even described to have a better outcome.

PATIENTS AND METHODS

We analyzed 283 patients (> or =75 years), undergoing AVR with or without concomitant CABG-procedures. We particularly analyzed those patients who were operated with an isolated AVR in spite of preoperatively known CAD. There were 166 patients in the AVR group (gr. A) and 117 patients in the AVR+CABG group (gr. AC). 51 of these patients with isolated AVR were preoperatively known to have an additional CAD (stenoses <60%) (gr. A2), whereas 115 patients of group A only suffered from an isolated aortic valve disease (gr. A1).

RESULTS

Comparing group A and AC, we found a significantly prolonged mechanical ventilation in group AC (22.3+/-5.3 hours vs 10.1+/-1.9 h in gr. A, p<0.05) and a longer stay on the ICU. The incidence of severe postoperative complications and the in-hospital mortality were comparable. In group A2 we could differ between stenoses of the LAD (n=19) and of the right coronary or circumflex artery (n=32). The decision not to bypass a stenosis of the LAD caused a significantly worse outcome of these patients compared to group AC. Ignoring stenoses of the RCA or RCx was not correlated with an impaired postoperative result.

CONCLUSIONS

With our results we could not identify concomitant CABG as a predictor of poor surgical outcome in elderly patients with AVR. We could even show that an additional bypass grafting of moderate stenoses of the LAD is important for a good outcome of these patients. Comparable stenoses in the right coronary or circumflex artery may be ignored with the advantage of a shorter period of intraoperative ischemia and the possibility of a secondary catheter intervention.

摘要

目的

因主动脉瓣置换术(AVR)而入院的老年人术前冠状动脉造影常显示冠状动脉(CAD)存在其他显著狭窄。在这些患者中同期进行冠状动脉旁路移植术(CABG)的益处仍存在争议。一些作者甚至描述,在合并CAD的老年患者中单纯进行AVR有更好的预后。

患者与方法

我们分析了283例年龄≥75岁、接受或未接受同期CABG手术的AVR患者。我们特别分析了那些尽管术前已知患有CAD但仍接受单纯AVR手术的患者。AVR组(A组)有166例患者,AVR + CABG组(AC组)有117例患者。这些接受单纯AVR手术的患者中,有51例术前已知合并CAD(狭窄<60%)(A2组),而A组的115例患者仅患有单纯主动脉瓣疾病(A1组)。

结果

比较A组和AC组,我们发现AC组机械通气时间显著延长(分别为22.3±5.3小时和A组的10.1±1.9小时,p<0.05),且在重症监护病房(ICU)的停留时间更长。术后严重并发症的发生率和院内死亡率相当。在A2组中,我们可以区分左前降支(LAD)狭窄(n = 19)和右冠状动脉或回旋支狭窄(n = 32)。与AC组相比,决定不对LAD狭窄进行旁路移植术导致这些患者的预后明显更差。忽略右冠状动脉(RCA)或回旋支(RCx)狭窄与术后结果受损无关。

结论

根据我们的结果,我们无法确定同期CABG是老年AVR患者手术预后不良的预测因素。我们甚至可以表明,对LAD中度狭窄进行额外的旁路移植术对这些患者的良好预后很重要。右冠状动脉或回旋支的类似狭窄可以忽略,其优点是术中缺血时间较短,且有可能进行二次导管介入。

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