Arévalo Maria Isabel, Escribano Elvira, Calpena Ana, Domenech Josep, Queralt Josep
Departament de Fisiologia-Divisió IV, Unitat de Biofarmàcia i Farmacocinètica, Universitat de Barcelona, Barcelona, Spain.
Inflammation. 2003 Oct;27(5):293-9. doi: 10.1023/a:1026076426664.
We examined the time course (7 weeks) of thermal hyperalgesia and light touch allodynia in rats after intradermal administration of Mycobacterium butyricum. Nociceptive thresholds to heat and light touch were assessed. Paw edema and temperature, motor function, body weight, and propioception were also tested. Some rats developed arthritis (named AA rats) but others did not (named non-AA rats). Both groups were compared with healthy animals. Persistent hyperalgesia was found in both groups; in AA rats it appeared before clinical evidence of arthritis. Transient allodynia ocurred only after edema development and fell when edema decreased. Motor function was impaired only in AA rats. The results of this study demonstrate that hyperalgesia, but not allodynia, appeared after Mycobacterium butyricum in both groups, suggesting that changes in sensitivity were not merely the result of local hypersensitivity of the inflamed tissue, but may also be due to alterations in nociception in the central nervous system.
我们研究了皮内注射丁酸分枝杆菌后大鼠热痛觉过敏和轻触觉异常性疼痛的时间进程（7周）。评估了对热和轻触觉的伤害性感受阈值。还测试了爪部水肿和温度、运动功能、体重以及本体感觉。一些大鼠发生了关节炎（称为AA大鼠），但其他大鼠未发生（称为非AA大鼠）。将两组与健康动物进行比较。两组均发现持续的痛觉过敏；在AA大鼠中，痛觉过敏出现在关节炎临床证据之前。短暂的异常性疼痛仅在水肿出现后发生，并在水肿减轻时消失。仅AA大鼠的运动功能受损。本研究结果表明，两组在注射丁酸分枝杆菌后均出现痛觉过敏而非异常性疼痛，这表明敏感性变化不仅仅是炎症组织局部超敏反应的结果，还可能归因于中枢神经系统伤害性感受的改变。
