Harris Margaret, Chandran Summit, Chakraborty Nabonita, Healy David
North Wales Department of Psychological Medicine, Hergest Unit, Bangor, UK.
Bipolar Disord. 2003 Dec;5(6):446-52. doi: 10.1046/j.1399-5618.2003.00069.x.
To review the history of 'mood-stabilizing' treatments.
We have reviewed primary source data on the origin of the use of current mood-stabilizers.
This historical record on the origins of the mood-stabilizers points to a more ambiguous picture as regards pharmacotherapeutic specificity to bipolar disorders than is commonly conceded.
This review suggests a need for alternative formulations of the concept of a mood-stabilizer. An alternative to the currently dominant paradigm is that these agents have treatment effects, which need to be matched more precisely with patients' constitutional types in order to optimize outcomes.
回顾“心境稳定剂”治疗的历史。
我们查阅了有关当前心境稳定剂使用起源的原始资料数据。
关于心境稳定剂起源的这一历史记录表明，与普遍认可的情况相比，双相情感障碍的药物治疗特异性方面的情况更为模糊。
本综述表明需要对心境稳定剂的概念进行替代表述。当前主导范式的一种替代观点是，这些药物具有治疗效果，为了优化治疗结果，需要使其与患者的体质类型更精确地匹配。
