Post R M, Denicoff K D, Frye M A, Dunn R T, Leverich G S, Osuch E, Speer A
Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892-1272, USA.
Neuropsychobiology. 1998 Oct;38(3):152-66. doi: 10.1159/000026532.
Anticonvulsants have moved into an important position as alternatives and adjuncts to lithium carbonate in the treatment of bipolar illness. Work with the nonhomologous model of kindled seizures helped in the choice of carbamazepine as a potential mood stabilizer and in the study of the mechanisms of action of the second generation anticonvulsants carbamazepine and valproate, as well as the putative third generation psychotropic anticonvulsants lamotrigine and gabapentin. Anticonvulsant neuropeptides such as TRH and nonconvulsant approaches with repeated transcranial magnetic stimulation (rTMS) also appear promising.
在双相情感障碍的治疗中，抗惊厥药物已成为碳酸锂的替代药物和辅助药物，占据重要地位。对点燃式癫痫发作的非同源模型的研究，有助于选择卡马西平作为一种潜在的情绪稳定剂，并有助于研究第二代抗惊厥药物卡马西平和丙戊酸盐以及第三代精神otropic抗惊厥药物拉莫三嗪和加巴喷丁的作用机制。抗惊厥神经肽如促甲状腺激素释放激素以及重复经颅磁刺激（rTMS）的非惊厥方法也显示出前景。
