Muller M J, Hollyoak M A, Moaveni Z, Brown Tim La H, Herndon D N, Heggers J P
Plastic Surgery and Burns Unit, Middlemore Hospital, P.O. Box 93311, Otahuhu, Auckland, New Zealand.
Burns. 2003 Dec;29(8):834-6. doi: 10.1016/s0305-4179(03)00198-0.
Inhibition of wound contraction by topical anti microbial agents has been described. The purpose of this study was to further investigate that phenomenon and to explore the effect that other agents such as Aloe vera might have on this process. Full-thickness excised wounds were created on the dorsum of Sprague-Dawley rats under anaesthesia. The wounds were treated with topical agents three times daily for fourteen days, then observed until healed. Groups were: saline control, placebo (aqueous cream) control, silver sulphadiazine (SSD) cream 1%, SSD 0.5%, SSD 1% with Aloe vera, SSD 1% with nystatin, nystatin. Wound surface areas were measured each three days. Time to 50% and 90% healing was compared using ANOVA. Wound half-life and healing times were shortest in the SSD/Aloe vera and nystatin groups (P<0.05) and longest in the 1% SSD and saline control groups. The placebo group (aqueous cream) healed in a significantly shorter time (P<0.05) than the control (saline) group. Wound contraction was delayed by saline and SSD. Nystatin and Aloe vera, when added to SSD, reversed that effect. These data suggest that a dry wound (saline) heals slowly. Infection control without delay of wound healing is most appealing and clinical trials are planned.
已有文献报道局部抗菌剂可抑制伤口收缩。本研究的目的是进一步探究这一现象，并探讨其他制剂如芦荟对该过程可能产生的影响。在麻醉状态下，于斯普拉格 - 道利大鼠背部制造全层切除伤口。伤口每日用局部制剂处理三次，持续十四天，然后观察直至愈合。分组如下：生理盐水对照组、安慰剂（水性乳膏）对照组、1%磺胺嘧啶银（SSD）乳膏组、0.5% SSD组、1% SSD与芦荟联合组、1% SSD与制霉菌素联合组、制霉菌素组。每三天测量伤口表面积。使用方差分析比较达到50%和90%愈合所需的时间。SSD/芦荟组和制霉菌素组的伤口半衰期和愈合时间最短（P<0.05），1% SSD组和生理盐水对照组最长。安慰剂组（水性乳膏）愈合时间明显短于对照组（生理盐水）（P<0.05）。生理盐水和SSD会延迟伤口收缩。制霉菌素和芦荟添加到SSD中可逆转这一效应。这些数据表明干燥伤口（生理盐水）愈合缓慢。在不延迟伤口愈合的情况下控制感染最具吸引力，目前正在计划进行临床试验。
