简单异尖线虫致敏与犬弓首蛔虫所致内脏幼虫移行症之间的交叉反应。

Cross-reactivity between Anisakis simplex sensitization and visceral larva migrans by Toxocara canis.

作者信息

Perteguer M J, Cuéllar C, Guillén J L, Aguila C, Fenoy S, Chivato T, Laguna R

机构信息

Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.

出版信息

Acta Trop. 2003 Dec;89(1):85-9. doi: 10.1016/s0001-706x(03)00201-8.

DOI:10.1016/s0001-706x(03)00201-8

PMID:14636986

Abstract

The aim of this work was to study cross-reactivity in the diagnosis of two related ascaridosis. Nineteen patients diagnosed with recidivous acute urticaria (RAU) caused by Anisakis simplex and 26 patients diagnosed with visceral larva migrans (VLM) caused by Toxocara canis were studied employing commercial diagnostic kits and "in house" assay kits. Cross-reactivity observed was greater when using "in house" assay kits, suggesting that T. canis excretory-secretory antigens were not only recognized by antibodies from patients with RAU but with greater intensity compared to the A. simplex excretory-secretory antigens.

摘要

这项工作的目的是研究两种相关蛔虫病诊断中的交叉反应性。使用商业诊断试剂盒和“自制”检测试剂盒，对19例被诊断为由简单异尖线虫引起的复发性急性荨麻疹（RAU）患者和26例被诊断为由犬弓首蛔虫引起的内脏幼虫移行症（VLM）患者进行了研究。使用“自制”检测试剂盒时观察到的交叉反应性更强，这表明犬弓首蛔虫排泄分泌抗原不仅能被RAU患者的抗体识别，而且与简单异尖线虫排泄分泌抗原相比，识别强度更高。