类风湿关节炎患者的中度高同型半胱氨酸血症与免疫激活
Moderate hyperhomocysteinaemia and immune activation in patients with rheumatoid arthritis.
作者信息
Schroecksnadel Katharina, Frick Barbara, Kaser Sabine, Wirleitner Barbara, Ledochowski Maximilian, Mur Erich, Herold Manfred, Fuchs Dietmar
机构信息
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Fritz Pregl Strasse 3, A-6020 Innsbruck, Austria.
出版信息
Clin Chim Acta. 2003 Dec;338(1-2):157-64. doi: 10.1016/j.cccn.2003.09.003.
BACKGROUND
Moderate hyperhomocysteinaemia related to folate deficiency has been described in patients with cardiovascular risk and also in patients with autoimmune diseases including rheumatoid arthritis (RA).
METHODS
In 33 patients with RA, serum concentrations of homocysteine and cysteine, of B-vitamins folate and vitamin B(12), and of immune activation markers neopterin and soluble 75-kDa TNF-receptor (sTNF-R75) were measured.
RESULTS
A significant proportion of patients presented with elevated homocysteine and cysteine concentrations in comparison to reference ranges of healthy control persons. Moderate hyperhomocysteinaemia coincided with decreased serum folate and with higher concentrations of sTNF-R75 and neopterin, but it was rather independent from methotrexate (MTX) therapy.
CONCLUSIONS
The coincidence of higher homocysteine and lower folate concentrations with increased concentrations of immune activation markers in patients with RA suggests that immune activation could be involved in the development of hyperhomocysteinaemia.
背景
与叶酸缺乏相关的中度高同型半胱氨酸血症已在有心血管风险的患者以及包括类风湿关节炎（RA）在内的自身免疫性疾病患者中被描述。
方法
对33例类风湿关节炎患者测定了同型半胱氨酸和半胱氨酸、B族维生素叶酸和维生素B12以及免疫激活标志物新蝶呤和可溶性75 kDa肿瘤坏死因子受体（sTNF-R75）的血清浓度。
结果
与健康对照者的参考范围相比，相当一部分患者的同型半胱氨酸和半胱氨酸浓度升高。中度高同型半胱氨酸血症与血清叶酸降低以及sTNF-R75和新蝶呤浓度升高同时出现，但与甲氨蝶呤（MTX）治疗关系不大。
结论
类风湿关节炎患者中较高的同型半胱氨酸和较低的叶酸浓度与免疫激活标志物浓度增加同时出现，提示免疫激活可能参与高同型半胱氨酸血症的发生。
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