Singh I, Lazo O, Kalipada P, Singh A K
Department of Pediatrics, Medical University of South Carolina, Charleston 29425.
Biochim Biophys Acta. 1992 Dec 10;1180(2):221-4. doi: 10.1016/0925-4439(92)90072-u.
We studied the oxidation of [1-14C]phytanic acid, 3-methyl substituted fatty acid, to pristanic acid and 14CO2 in human skin fibroblasts. The specific activity for alpha-oxidation of phytanic acid in peroxisomes was 29- and 124-fold higher than mitochondria and endoplasmic reticulum. This finding demonstrates for the first time the presence of fatty acid alpha-oxidation enzyme system in peroxisomes.
我们研究了[1-¹⁴C]植烷酸（3-甲基取代脂肪酸）在人皮肤成纤维细胞中氧化为降植烷酸和¹⁴CO₂的过程。过氧化物酶体中植烷酸α-氧化的比活性比线粒体和内质网分别高29倍和124倍。这一发现首次证明了过氧化物酶体中存在脂肪酸α-氧化酶系统。
