Hyam D M, Conway R C, Sathiyaseelan Y, Gebski V, Morgan G J, Walker D M, Veness M J
Department of Oral and Maxillofacial Surgery, Westmead Hospital, Sydney.
Aust Dent J. 2003 Mar;48(1):50-4. doi: 10.1111/j.1834-7819.2003.tb00009.x.
Debate continues as to whether being young confers a worse prognosis for patients with squamous cell carcinoma of the tongue. Recent papers have provided conflicting views in this debate. In this study we aimed to investigate if young age at the time of diagnosis of squamous cell carcinoma of the tongue confers a worse prognosis.
Eligible patients were identified through the computer database of the Department of Radiation Oncology, Westmead Hospital, Sydney. All eligible patients were treated with radical intent. Using age 40 as a cut off multivariate and survival analysis was undertaken to compare age groups.
Median age at diagnosis was 60 years (range, 19-86 years) in 84 males (65 per cent) and 45 females (35 per cent). Median follow-up time was 43 months (range, 2.3-203 months). Fifteen patients (12 per cent) were aged <40 years. On univariate analysis stage and age were significant determinants of disease-specific survival. There was no difference in overall survival between the young (<40 years) and middle-aged groups (40-60 years). However, the young and the middle aged were both more likely to survive than the older age group (>60 years). On multivariate analysis age remained a significant factor for determining disease-specific survival, with the older age group 2.9 times more likely to die than the younger groups.
Young age (<40 years) did not portend to worse survival in comparison to older tongue cancer patients.
关于年轻是否会使舌鳞状细胞癌患者的预后更差，目前仍存在争议。近期的论文在这场争论中给出了相互矛盾的观点。在本研究中，我们旨在调查舌鳞状细胞癌诊断时年龄较轻是否意味着预后更差。
通过悉尼韦斯特米德医院放射肿瘤学系的计算机数据库确定符合条件的患者。所有符合条件的患者均接受根治性治疗。以40岁为界进行多变量和生存分析，以比较不同年龄组。
84例男性（65%）和45例女性（35%）的诊断时中位年龄为60岁（范围19 - 86岁）。中位随访时间为43个月（范围2.3 - 203个月）。15例患者（12%）年龄<40岁。单变量分析显示，分期和年龄是疾病特异性生存的重要决定因素。年轻组（<40岁）和中年组（40 - 60岁）的总生存率无差异。然而，年轻组和中年组的生存率均高于老年组（>60岁）。多变量分析显示，年龄仍然是决定疾病特异性生存的重要因素，老年组死亡的可能性是年轻组的2.9倍。
与老年舌癌患者相比，年轻（<40岁）并不预示着生存率更差。
