Benrud-Larson Lisa M, Sandroni Paola, Haythornthwaite Jennifer A, Rummans Teresa A, Low Phillip A
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Health Psychol. 2003 Nov;22(6):643-8. doi: 10.1037/0278-6133.22.6.643.
The study investigated correlates of functional disability in 94 patients (89.4% women, 10.6% men; mean age=34.2 years) with postural tachycardia syndrome (POTS), a clinical syndrome of orthostatic intolerance characterized by significant functional limitations. Path analysis supported a model in which, controlling for demographic and disease variables, catastrophic cognitions were directly related to the latent variable functional disability, whereas somatic vigilance, anxiety sensitivity, and neuroticism were indirectly associated with functional disability through their relationship with catastrophic cognitions. Results suggest that modifiable psychological factors play a role in the functional limitations experienced by patients with POTS. Longitudinal research is necessary to confirm these relationships.
该研究调查了94例姿势性心动过速综合征（POTS）患者（89.4%为女性，10.6%为男性；平均年龄=34.2岁）功能残疾的相关因素，POTS是一种体位不耐受的临床综合征，其特征为存在显著的功能限制。路径分析支持了一个模型，即在控制人口统计学和疾病变量的情况下，灾难性认知与潜在变量功能残疾直接相关，而躯体警觉性、焦虑敏感性和神经质则通过它们与灾难性认知的关系与功能残疾间接相关。结果表明，可改变的心理因素在POTS患者经历的功能限制中起作用。需要进行纵向研究来证实这些关系。
