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体位性心动过速综合征患者的生活质量

Quality of life in patients with postural tachycardia syndrome.

作者信息

Benrud-Larson Lisa M, Dewar Melanie S, Sandroni Paola, Rummans Teresa A, Haythornthwaite Jennifer A, Low Phillip A

机构信息

Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.

出版信息

Mayo Clin Proc. 2002 Jun;77(6):531-7. doi: 10.4065/77.6.531.

Abstract

OBJECTIVES

To quantify quality of life and identify demographic and clinical correlates of functioning in a well-characterized sample of patients with postural tachycardia syndrome (POTS).

PATIENTS AND METHODS

Prospective patients were those seen at the Mayo Clinic Autonomic Disorders Laboratory from September 2000 to June 2001. Neurologists made diagnoses of POTS according to established criteria. Patients completed a questionnaire packet that included measures of quality of life (36-Item Short-Form Health Survey [SF-36]) and symptom severity (Autonomic Symptom Profile). Additional clinical information was abstracted from medical records.

RESULTS

Ninety-four patients (89% female; mean age, 34.2 years) were enrolled in the study. Patients with POTS reported impairment across multiple domains on the SF-36. Physical functioning, role functioning, bodily pain, general health, vitality, and social functioning were all significantly impaired compared with a healthy population (P<.01 for all) and similar to that reported by patients with other chronic, disabling conditions. Hierarchical regression analyses revealed that symptom severity (beta = -.36, P<.001) and disability status (beta = -36, P<.001) were independent predictors of SF-36 physical component scores, with the full model accounting for 54% of the variance (P<.001). None of the variables examined accounted for a significant amount of the variance in SF-36 mental component scores.

CONCLUSIONS

Patients with POTS experience clear limitations across multiple domains of quality of life, including physical, social, and role functioning. Treatment should address the multiple and varied impairments experienced by these patients and may require a multidisciplinary approach. Future research must further delineate factors, both disease related and psychosocial, that predict functioning and adjustment in this population.

摘要

目的

在特征明确的直立性心动过速综合征(POTS)患者样本中,量化生活质量并确定功能状态的人口统计学和临床相关因素。

患者与方法

前瞻性研究的患者为2000年9月至2001年6月在梅奥诊所自主神经紊乱实验室就诊的患者。神经科医生根据既定标准诊断POTS。患者完成一套问卷,其中包括生活质量测量(36项简短健康调查[SF-36])和症状严重程度测量(自主神经症状概况)。从病历中提取其他临床信息。

结果

94名患者(89%为女性;平均年龄34.2岁)纳入研究。POTS患者在SF-36的多个领域报告有功能损害。与健康人群相比,身体功能、角色功能、身体疼痛、总体健康、活力和社会功能均显著受损(均P<0.01),且与其他慢性致残性疾病患者报告的情况相似。分层回归分析显示,症状严重程度(β=-0.36,P<0.001)和残疾状态(β=-0.36,P<0.001)是SF-36身体成分得分的独立预测因素,完整模型解释了54%的方差(P<0.001)。所检查的变量均未解释SF-36心理成分得分中显著比例的方差。

结论

POTS患者在生活质量的多个领域,包括身体、社会和角色功能方面,都存在明显的限制。治疗应针对这些患者所经历的多种不同损害,可能需要多学科方法。未来的研究必须进一步明确预测该人群功能和适应情况的疾病相关和心理社会因素。

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