Ozdemir S, Ayaz M, Tuncer T, Ugur M, Turan B
Department of Biophysics, Faculty of Medicine, Ankara University, Turkey.
Physiol Res. 2003;52(6):767-71.
The aim of this study is to define the possible effects of vegetable oils used as vitamin E vehicle on the electrical activity of the rat heart. To test the possible effects of vitamin E vehicles we studied the effect of i.p. injected corn oil, hazelnut oil or peanut oil on the action potential parameters recorded in both papillary and left atrial muscle strips. Four experimental groups were used. The control group was injected (i.p.) with distilled water, while the three remaining groups received injections of corn oil, hazelnut oil, or peanut oil for five weeks (in a dose of 0.4 ml/kg/day--minimum amount of oil in which vitamin E could be dissolved). We used borosilicated (15-20 megaohms) capillary electrodes and intracellular action potentials (AP) were recorded in isolated papillary and left atrium muscle strips. While administration of three different types of vegetable oil had no significant effect on AP parameters of papillary muscle, they significantly prolonged the repolarization phase of AP in atrial strips. These results show that vegetable oils used as vitamin E vehicles may alter the electrical activity of the heart in a tissue-dependent manner. The present data indicate that the possible effect of vegetable oil vehicles should be kept in mind while evaluating the possible effects of in vivo vitamin E administration.
本研究的目的是确定用作维生素E载体的植物油对大鼠心脏电活动的可能影响。为了测试维生素E载体的可能影响，我们研究了腹腔注射玉米油、榛子油或花生油对乳头肌和左心房肌条记录的动作电位参数的影响。使用了四个实验组。对照组腹腔注射蒸馏水，其余三组连续五周注射玉米油、榛子油或花生油（剂量为0.4毫升/千克/天——维生素E能够溶解的最小油量）。我们使用硼硅酸盐（15 - 20兆欧）毛细管电极，在分离的乳头肌和左心房肌条中记录细胞内动作电位（AP）。虽然三种不同类型的植物油给药对乳头肌的AP参数没有显著影响，但它们显著延长了心房肌条中AP的复极化阶段。这些结果表明，用作维生素E载体的植物油可能以组织依赖的方式改变心脏的电活动。目前的数据表明，在评估体内给予维生素E的可能影响时，应考虑植物油载体的可能作用。
