Fujimoto A, Enomoto T, Takano S, Nose T
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
J Clin Neurosci. 2004 Jan;11(1):69-70. doi: 10.1016/s0967-5868(03)00068-7.
Carbamazepine (CBZ) is frequently used to treat patients with epilepsy, neuralgia, psychiatric diseases, etc. We prescribe it with care due to its side effects, mainly such as dizziness, sleepiness and cerebellar symptoms. But pitch perception abnormality is an uncommon side effect. We describe the case of a 12-year-old girl who exhibited half tone lowered pitch perception abnormality caused by CBZ. As CBZ acts as a central nervous system (CNS) inhibitor, we speculate that CBZ inhibits CNS and patients misperceive notes. We must prescribe CBZ with care to prevent pitch perception abnormalities.
卡马西平（CBZ）常用于治疗癫痫、神经痛、精神疾病等患者。由于其副作用，主要如头晕、嗜睡和小脑症状，我们在开此药时会谨慎。但音高感知异常是一种不常见的副作用。我们描述了一名12岁女孩的病例，她出现了由卡马西平引起的半音降低的音高感知异常。由于卡马西平作为一种中枢神经系统（CNS）抑制剂，我们推测卡马西平抑制中枢神经系统，导致患者对音符产生错误感知。我们必须谨慎开卡马西平以预防音高感知异常。
