慢性乙型肝炎病毒/丙型肝炎病毒感染的流行病学和临床负担：一项意大利多中心研究。

Epidemiological and clinical burden of chronic hepatitis B virus/hepatitis C virus infection. A multicenter Italian study.

作者信息

Gaeta Giovanni B, Stornaiuolo Gianfranca, Precone Davide F, Lobello Salvatore, Chiaramonte Maria, Stroffolini Tommaso, Colucci Giuseppe, Rizzetto Mario

机构信息

Department of Medicine and Public Health, Unit of Infectious Diseases, Second University of Naples, Via Cotugno, 1 C/O Osp. Gesù e Maria, 80135 Naples, Italy.

出版信息

J Hepatol. 2003 Dec;39(6):1036-41. doi: 10.1016/s0168-8278(03)00470-7.

DOI:10.1016/s0168-8278(03)00470-7

PMID:14642623

Abstract

BACKGROUND/AIMS: This study assess prevalence, risk factors, and clinical and virological features of dual hepatitis B virus (HBV)/hepatitis C virus (HCV) infection.

METHODS

We evaluated 837 hepatitis B surface antigen positive patients, prospectively enrolled in 14 Italian units.

RESULTS

Anti-HCV was present in 59 cases (7%); age specific prevalences were 4.5% (0-30 years), 4.4% (>30-50) and 14% (>50). Independent predictors of dual infection were age >42 years, history of I.V. drug use (IDU), blood transfusion and residence in the South of the country. The strength of the association with IDU was high, but this exposure accounted for five coinfection cases only. Cirrhosis was present in 107 of the 709 patients with HBV alone (15.1%), in 30 of 69 with hepatitis D virus coinfection (43%) and in 17 of 59 with HCV coinfection (28.8%); a light alcohol use was marginally associated with cirrhosis. Of 36 B/C coinfected patients, 16 (44.4%) had only HBV-DNA in serum, (median age=47.5 years) five (13.9%) had both HBV-DNA and HCV-RNA (age=53), nine (25%) had HCV-RNA alone (age=59) and six (16.7%) tested negative for both.

CONCLUSIONS

This study depicts the epidemiological and clinical burden of dual HBV/HCV infection in Italy.

摘要

背景/目的：本研究评估乙型肝炎病毒（HBV）/丙型肝炎病毒（HCV）双重感染的患病率、危险因素以及临床和病毒学特征。

方法

我们评估了前瞻性纳入意大利14个单位的837例乙型肝炎表面抗原阳性患者。

结果

59例（7%）患者抗-HCV阳性；按年龄划分的患病率分别为4.5%（0至30岁）、4.4%（>30至50岁）和14%（>50岁）。双重感染的独立预测因素为年龄>42岁、静脉注射吸毒史（IDU）、输血史以及居住在该国南部。与IDU的关联强度较高，但这种暴露仅导致5例合并感染。709例仅感染HBV的患者中有107例（15.1%）发生肝硬化，69例合并丁型肝炎病毒感染的患者中有30例（43%）发生肝硬化，59例合并HCV感染的患者中有17例（28.8%）发生肝硬化；轻度饮酒与肝硬化有微弱关联。在36例B/C合并感染患者中，16例（44.4%）血清中仅检测到HBV-DNA（中位年龄=47.5岁），5例（13.9%）同时检测到HBV-DNA和HCV-RNA（年龄=53岁），9例（25%）仅检测到HCV-RNA（年龄=59岁），6例（16.7%）两者均检测为阴性。