Brambilla Paolo, Nicoletti Mark A, Sassi Roberto B, Mallinger Alan G, Frank Ellen, Kupfer David J, Keshavan Matcheri S, Soares Jair C
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Biol Psychiatry. 2003 Dec 1;54(11):1294-7. doi: 10.1016/s0006-3223(03)00070-2.
This study was conducted to further examine the hypothesis of abnormalities in size of corpus callosum in subjects with bipolar disorder.
Sixteen right-handed DSM-IV bipolar I patients and 27 right-handed healthy control subjects were studied. A 1.5-T GE Signa magnet was used, and three-dimensional gradient echo imaging (spoiled gradient recall acquisition) was conducted. Area measurements of corpus callosum were obtained blindly, with a semi-automated software, by a well-trained rater.
Right-handed bipolar I patients had significantly smaller total corpus callosum, genu, posterior body, and isthmus areas compared with right-handed healthy control subjects (analysis of covariance with age, gender, and intracranial volume as covariates, p <.05). Partial correlation analyses, controlled for intracranial volumes, found a significant inverse relationship between age and total callosal, genu, anterior body, isthmus, and circularity in healthy control subjects (p <.05) but not in bipolar patients (p >.05).
Smaller callosal areas may lead to altered inter-hemispheric communication and be involved in the pathophysiology and cognitive impairment found in bipolar disorder.
本研究旨在进一步检验双相情感障碍患者胼胝体大小异常这一假设。
对16名右利手的DSM-IV双相I型患者和27名右利手的健康对照者进行研究。使用1.5-T的GE Signa磁体，并进行三维梯度回波成像（扰相梯度回波采集）。由一名训练有素的评估者使用半自动软件对胼胝体进行盲法面积测量。
与右利手的健康对照者相比，右利手的双相I型患者胼胝体、膝部、后部和峡部的总面积显著更小（以年龄、性别和颅内体积作为协变量进行协方差分析，p <.05）。在控制颅内体积的偏相关分析中，发现健康对照者的年龄与胼胝体总面积、膝部、前部、峡部和圆形度之间存在显著的负相关（p <.05），而双相情感障碍患者中则不存在这种相关性（p >.05）。
胼胝体面积减小可能导致半球间沟通改变，并参与双相情感障碍的病理生理过程和认知障碍。
