Atmaca Murad, Ozdemir Huseyin, Yildirim Hanefi
Department of Psychiatry, Firat University, Elazig, Turkey.
Psychol Med. 2007 May;37(5):699-704. doi: 10.1017/S0033291706009743. Epub 2007 Jan 16.
Morphological changes in the corpus callosum (CC) have been described in bipolar disorder, but with inconsistencies among the reports. We investigated the CC areas by magnetic resonance imaging (MRI) in 12 first-episode patients with bipolar disorder and 12 controls.
Twelve medication-naive patients with bipolar I disorder (six males, six females; aged 28 x 2+/-6 x 5 years) with manic or mixed episodes and 12 age- and gender-matched healthy controls (six males, six females; aged 26 x 8+/-7 x 6 years) were recruited to the study. MRI scans was obtained using a 1.5-T GE Signa Excite high-speed scanner. Anatomical measurements were conducted on a computer workstation with the software Scion Image Beta-3b for Windows. Statistical analysis was performed using an analysis of covariance (ANCOVA), the t test, chi2 and partial correlation analyses.
Bipolar patients had significantly smaller areas of total CC, anterior body posterior body and isthmus compared with healthy control subjects by ANCOVA, with age, gender and intracranial volume (ICV) as covariates. There was a negative correlation between total CC, posterior body and isthmus areas and Young Mania Rating Scale (YMRS) scores.
The findings suggest that CC morphology may be associated with the pathophysiology of bipolar disorder.
双相情感障碍患者胼胝体（CC）的形态学变化已有相关描述，但报告结果并不一致。我们通过磁共振成像（MRI）对12例双相情感障碍首发患者和12名对照者的CC区域进行了研究。
招募12例未服用过药物的双相I型障碍患者（6例男性，6例女性；年龄28×2±6×5岁），均有躁狂或混合发作，以及12名年龄和性别匹配的健康对照者（6例男性，6例女性；年龄26×8±7×6岁）参与本研究。使用1.5-T GE Signa Excite高速扫描仪进行MRI扫描。在装有适用于Windows的Scion Image Beta-3b软件的计算机工作站上进行解剖测量。采用协方差分析（ANCOVA）、t检验、卡方检验和偏相关分析进行统计分析。
以年龄、性别和颅内体积（ICV）作为协变量，通过ANCOVA分析发现，双相情感障碍患者的CC总体积、胼胝体前部、后部和峡部面积显著小于健康对照者。CC总体积、后部和峡部面积与杨氏躁狂评定量表（YMRS）评分呈负相关。
研究结果表明，CC形态可能与双相情感障碍的病理生理学有关。
