Adrian J. Lloyd, MB, BS, MRCPsych, MD (Hons), Heba E. Ali, MB, BS, Mphil, David Nesbitt, BSc (Hons), MB, BS, P. Brian Moore, PhD, MB, BS, FRCPsych, Allan H. Young, MB, ChB, MPhil, PhD, FRCPsych, FRCPS, I. Nicol Ferrier, BSc(Hons), MD (Hons), FRCP(Ed), FRCPsych, Psychobiology Research Group, Institute of Neuroscience, Newcastle University, Newcastle-upon-Tyne, UK.
Br J Psychiatry. 2014 Feb;204(2):129-36. doi: 10.1192/bjp.bp.112.123687. Epub 2013 Dec 19.
Changes in corpus callosum area and thickness have been reported in bipolar disorder. Imaging and limited neuropathological data suggest possible abnormalities in myelination and/or glial function.
To compare corpus callosum area, thickness and magnetic resonance imaging (MRI) T1 signal intensity in patients with bipolar disorder and healthy controls.
A total of 48 patients with euthymic bipolar disorder and 46 healthy controls underwent MRI analysis of callosal midsagittal area, callosal thickness and T1 signal intensity.
The bipolar group had smaller overall and subregional callosal areas and correspondingly reduced callosal width than the control group. Age correlated negatively with callosal area in the control group but not in the bipolar group. Signal intensity was higher in women than in men in both groups. Signal intensity was reduced in women, but not in men, in the bipolar group.
Observed differences probably relate to diagnosis rather than mood state and bipolar disorder appears to result in morphometric change that overrides changes seen in normal ageing. Intensity changes are consistent with possible altered myelination or glial function. A gender-dependent factor appears to operate and to interact with diagnosis.
双相情感障碍患者的胼胝体面积和厚度发生变化。影像学和有限的神经病理学数据表明髓鞘形成和/或神经胶质功能可能存在异常。
比较双相情感障碍患者和健康对照者的胼胝体面积、厚度和磁共振成像（MRI）T1 信号强度。
共有 48 名病情稳定的双相情感障碍患者和 46 名健康对照者接受了胼胝体正中矢状面面积、胼胝体厚度和 T1 信号强度的 MRI 分析。
与对照组相比，双相组的整体和各区域胼胝体面积以及相应的胼胝体宽度更小。对照组的年龄与胼胝体面积呈负相关，但双相组则没有。两组中女性的信号强度均高于男性。双相组中女性的信号强度降低，但男性没有。
观察到的差异可能与诊断有关，而与情绪状态无关，且双相情感障碍似乎导致形态变化，从而掩盖了正常衰老过程中的变化。强度变化与可能改变的髓鞘形成或神经胶质功能一致。似乎存在一个性别依赖性因素，并与诊断相互作用。
