Coleman Paul D, Yao Pamela J
Univesity of Rochester, Center for Aging and Developmental Biology, Rochester, NY 14642, USA.
Neurobiol Aging. 2003 Dec;24(8):1023-7. doi: 10.1016/j.neurobiolaging.2003.09.001.
Synaptic loss is currently established as the best neurobiological correlate of the cognitive deficits of Alzheimer's disease (AD) [Ann. Neurol. 27 (1990) 457; Ann. Neurol. 30 (1991) 572]. We provide evidence that still living neurons lose synapses in AD, in addition to the synapse loss due to death of neurons. We also provide evidence indicating that in addition to loss of synapses, synaptic function is also affected in AD by decrements in transcript species related to synaptic vesicle trafficking.
目前，突触丧失已被确认为阿尔茨海默病（AD）认知缺陷的最佳神经生物学关联指标[《神经病学纪事》27卷（1990年）第457页；《神经病学纪事》30卷（1991年）第572页]。我们提供的证据表明，在AD中，除了因神经元死亡导致的突触丧失外，仍然存活的神经元也会丧失突触。我们还提供了证据表明，除了突触丧失外，AD中的突触功能还会受到与突触小泡运输相关转录物种类减少的影响。
