与肿瘤坏死因子-α全身给药相关的神经化学致敏作用：与牛血清白蛋白联合的佐剂作用

Neurochemical sensitization associated with systemic administration of tumor necrosis factor-alpha: adjuvant action in combination with bovine serum albumin.

作者信息

Anisman Hymie, Turrin Nicolas P, Merali Zul, Hayley Shawn

机构信息

Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada K1S 5B6.

出版信息

J Neuroimmunol. 2003 Dec;145(1-2):91-102. doi: 10.1016/j.jneuroim.2003.09.014.

DOI:10.1016/j.jneuroim.2003.09.014

PMID:14644035

Abstract

Tumor necrosis factor-alpha (TNF-alpha) provokes a time-dependent sensitization of brain monoamine activity, plasma corticosterone activity and sickness behavior, the latter being reminiscent of septic or anaphylactic shock. In this investigation, bovine serum albumin (BSA) elicited similar corticosterone and sickness profiles, whereas the monoamine changes were not observed. The sensitization elicited by mTNF-alpha plus BSA was markedly greater than that elicited by BSA alone. Carrier-free TNF-alpha promoted the sensitization of brain monoamine activity, but not sickness or corticosterone. It is suggested that mTNF-alpha acts as an adjuvant to the anaphylactic actions elicited by BSA, but may provoke a sensitization of monoamine activity which is time-dependent and varies across brain regions.

摘要

肿瘤坏死因子-α（TNF-α）可引发脑单胺活性、血浆皮质酮活性和疾病行为随时间的敏感性增加，后者类似于败血症或过敏性休克。在本研究中，牛血清白蛋白（BSA）引发了类似的皮质酮和疾病特征，而未观察到单胺变化。mTNF-α加BSA引发的敏感性明显大于单独使用BSA引发的敏感性。无载体TNF-α促进了脑单胺活性的敏感性增加，但未促进疾病或皮质酮的敏感性增加。提示mTNF-α作为BSA引发的过敏反应的佐剂，但可能引发单胺活性的敏感性增加，这种增加具有时间依赖性且在不同脑区有所不同。