维生素A对胃内给予牛血清白蛋白后的全身及局部抗体反应的影响。
Effect of vitamin A on the systemic and local antibody responses to intragastrically administered bovine serum albumin.
作者信息
Falchuk K R, Walker W A, Perrotto J L, Isselbacher K J
出版信息
Infect Immun. 1977 Aug;17(2):361-5. doi: 10.1128/iai.17.2.361-365.1977.
Abstract
The effects of vitamin A on the immune response to bovine serum albumin (BSA) were studied in adult mice. Treatment with vitamin A by the intragastric or parenteral routes markedly increased the local as well as the systemic antibody response to different concentrations of the antigen (BSA). In contrast, in animals given BSA alone, antigen concentrations above a certain dose resulted in a decreased or even absent anti-BSA response. These studies suggest that vitamin A may be an appropriate adjuvant in oral immunization.
摘要
研究了维生素A对成年小鼠针对牛血清白蛋白（BSA）免疫反应的影响。通过胃内或肠胃外途径给予维生素A，显著增强了对不同浓度抗原（BSA）的局部和全身抗体反应。相比之下，在仅给予BSA的动物中，高于一定剂量的抗原浓度导致抗BSA反应降低甚至缺失。这些研究表明，维生素A可能是口服免疫中一种合适的佐剂。
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