Tops M, van der Pompe G, Wijers A A, Den Boer J A, Meijman T F, Korf J
Department of Psychiatry, University of Groningen and Graduate School of Behavioral and Cognitive Neurosciences, Grote Kruisstraat 2/1, 9712 TS, Groningen, The Netherlands.
Psychoneuroendocrinology. 2004 Apr;29(3):327-38. doi: 10.1016/s0306-4530(03)00032-5.
In a recent study we investigated the acute effects of cortisol administration in healthy male volunteers on free recall of pleasant, unpleasant, and neutral nouns using a between-subjects double-blind placebo-controlled design. The volunteers were administered 10 mg of hydrocortisone or placebo between 9:00 and 10:30. Two hours after administration of cortisol a decline in recall of neutral and pleasant words was found, while recall of unpleasant words did not change. These results are consistent with a possible inhibitory influence of cortisol on a prefrontal dopaminergic mechanism involved in approach and positivity bias. In this paper we first explain why this interpretation would predict recall of pleasant words from recency positions to be especially sensitive to cortisol administration. Comparing primacy and recency recall of pleasant and unpleasant words, there proved to be a selective decline in recall of pleasant recency words. These results did not appear to stem from differences in recall strategies between our groups of volunteers.
在最近的一项研究中，我们采用组间双盲安慰剂对照设计，调查了给健康男性志愿者注射皮质醇对其自由回忆愉快、不愉快和中性名词的急性影响。志愿者在9:00至10:30之间接受10毫克氢化可的松或安慰剂注射。注射皮质醇两小时后，发现对中性和愉快词汇的回忆有所下降，而对不愉快词汇的回忆没有变化。这些结果与皮质醇可能对参与趋近和积极偏向的前额叶多巴胺能机制产生抑制作用一致。在本文中，我们首先解释为什么这种解释会预测从新近位置回忆愉快词汇对注射皮质醇特别敏感。比较愉快和不愉快词汇的首因和近因回忆，发现愉快近因词汇的回忆存在选择性下降。这些结果似乎并非源于我们志愿者组之间回忆策略的差异。
