Pedrazzoli Mario, D'Almeida Vania, Martins Paulo J F, Machado Ricardo B, Ling Lin, Nishino Seiji, Tufik Sergio, Mignot Emmanuel
Department of Psychobiology/Sleep Institute, Universidade Federal de São Paulo, Rua Napoleao de Barros 925, São Paulo, SP, CEP: 04024-002, Brazil.
Brain Res. 2004 Jan 2;995(1):1-6. doi: 10.1016/j.brainres.2003.09.032.
Rat cisternal (CSF) hypocretin-1 in cerebrospinal fluid was measured after 6 or 96 h of REM sleep deprivation and following 24 h of REM sleep rebound. REM deprivation was found to increase CSF hypocretin-1 collected at zeitgeber time (ZT) 8 but not ZT0. Decreased CSF hypocretin levels were also observed at ZT8 after 24 h of REM sleep rebound. These results suggest that REM sleep deprivation activates and REM sleep rebound inhibits the hypocretin system. Increased hypocretin tone during REM deprivation may be important in mediating some of the effects of REM sleep deprivation such as antidepressant effects, hyperphagia and increased sympathetic activity.
在快速眼动睡眠剥夺6小时或96小时后以及快速眼动睡眠反弹24小时后，测量大鼠脑脊液中的下丘脑分泌素-1。发现快速眼动睡眠剥夺会增加在生物钟时间（ZT）8收集的脑脊液下丘脑分泌素-1，但在ZT0时不会。在快速眼动睡眠反弹24小时后的ZT8也观察到脑脊液下丘脑分泌素水平降低。这些结果表明，快速眼动睡眠剥夺激活而快速眼动睡眠反弹抑制下丘脑分泌素系统。快速眼动睡眠剥夺期间下丘脑分泌素张力增加可能在介导快速眼动睡眠剥夺的一些效应（如抗抑郁作用、食欲亢进和交感神经活动增加）中起重要作用。
