Division of Child Neurology, Department of Pediatrics, Cohen Children's Medical Center, 2001 Marcus Ave, Suite W290, New Hyde Park, NY, 11042, USA.
Curr Neurol Neurosci Rep. 2022 Sep;22(9):551-563. doi: 10.1007/s11910-022-01219-1. Epub 2022 Jul 8.
To review the mutual interactions between sleep and epilepsy, including mechanisms of epileptogenesis, the relationship between sleep apnea and epilepsy, and potential strategies to treat seizures.
Recent studies have highlighted the role of functional network systems underlying epileptiform activation in sleep in several epilepsy syndromes, including absence epilepsy, benign focal childhood epilepsy, and epileptic encephalopathy with spike-wave activation in sleep. Sleep disorders are common in epilepsy, and early recognition and treatment can improve seizure frequency and potentially reduce SUDEP risk. Additionally, epilepsy is associated with cyclical patterns, which has led to new treatment approaches including chronotherapy, seizure monitoring devices, and seizure forecasting. Adenosine kinase and orexin receptor antagonists are also promising new potential drug targets that could be used to treat seizures. Sleep and epilepsy have a bidirectional relationship that intersects with many aspects of clinical management. In this article, we identify new areas of research involving future therapeutic opportunities in the field of epilepsy.
回顾睡眠与癫痫之间的相互作用，包括致痫机制、睡眠呼吸暂停与癫痫的关系，以及潜在的治疗癫痫发作的策略。
最近的研究强调了几种癫痫综合征中睡眠中癫痫样激活的功能网络系统的作用，包括失神癫痫、良性局灶性儿童癫痫和伴睡眠中棘慢波发放的癫痫性脑病。睡眠障碍在癫痫中很常见，早期识别和治疗可以改善癫痫发作频率，并可能降低 SUDEP 风险。此外，癫痫与周期性模式相关，这导致了新的治疗方法，包括时间疗法、癫痫监测设备和癫痫预测。腺苷激酶和食欲素受体拮抗剂也是有前途的新的潜在药物靶点，可用于治疗癫痫发作。睡眠和癫痫之间存在双向关系，与临床管理的许多方面相互交叉。在本文中，我们确定了涉及癫痫领域未来治疗机会的新的研究领域。
