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PDGF increases the expression of Fos and Jun in newly formed oligodendrocytes that have become resistant to the mitogenic effect of PDGF.

作者信息

Hart I K, Richardson W D, Raff M C

机构信息

MRC Developmental Neurobiology Programme, University College London, United Kingdom.

出版信息

Glia. 1992;6(4):310-3. doi: 10.1002/glia.440060409.

DOI:10.1002/glia.440060409
PMID:1464462
Abstract

Bipotential glial (O-2A) progenitor cells give rise to oligodendrocytes on a predictable schedule in the developing rat optic nerve. The loss of mitotic responsiveness to platelet-derived growth factor (PDGF) that is seen when O-2A progenitor cells initially differentiate into oligodendrocytes seems to reflect blocks or deficiencies downstream to some of the early intracellular signalling events induced by PDGF. Here we show that PDGF increases the expression of the Fos and Jun nuclear proteins in newly formed oligodendrocytes in vitro, suggesting that at least one intracellular signalling pathway to the nucleus is activated by PDGF in these cells even though they do not synthesize DNA in response to PDGF.

摘要

相似文献

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PDGF increases the expression of Fos and Jun in newly formed oligodendrocytes that have become resistant to the mitogenic effect of PDGF.
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2
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PDGF A chain homodimers drive proliferation of bipotential (O-2A) glial progenitor cells in the developing rat optic nerve.血小板衍生生长因子A链同二聚体驱动发育中大鼠视神经内双潜能（O-2A）神经胶质祖细胞的增殖。
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引用本文的文献

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Int J Physiol Pathophysiol Pharmacol. 2010;2(2):137-47. Epub 2010 Jun 12.
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Platelet-derived growth factor promotes repair of chronically demyelinated white matter.
血小板衍生生长因子促进慢性脱髓鞘白质的修复。
J Neuropathol Exp Neurol. 2007 Nov;66(11):975-88. doi: 10.1097/NEN.0b013e3181587d46.
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Developing Schwann cells acquire the ability to survive without axons by establishing an autocrine circuit involving insulin-like growth factor, neurotrophin-3, and platelet-derived growth factor-BB.发育中的施万细胞通过建立一个涉及胰岛素样生长因子、神经营养因子-3和血小板衍生生长因子-BB的自分泌回路，获得了在没有轴突的情况下存活的能力。
J Neurosci. 1999 May 15;19(10):3847-59. doi: 10.1523/JNEUROSCI.19-10-03847.1999.