Cheng Allen C, Lowe Michael, Stephens Dianne P, Currie Bart J
Menzies School of Health Research and Northern Territory Clinical School, Flinders University, PO Box 41096, Casuarina NT 0811, Darwin, Australia.
BMJ. 2003 Nov 29;327(7426):1280-2. doi: 10.1136/bmj.327.7426.1280.
When mortality from melioidosis fell sharply after multiple changes in management at an Australian hospital, doctors wanted to identify whether a new drug was responsible. But designing a trial that was ethically acceptable proved impossible