评估类鼻疽新疗法的伦理问题。
Ethical problems of evaluating a new treatment for melioidosis.
作者信息
Cheng Allen C, Lowe Michael, Stephens Dianne P, Currie Bart J
机构信息
Menzies School of Health Research and Northern Territory Clinical School, Flinders University, PO Box 41096, Casuarina NT 0811, Darwin, Australia.
出版信息
BMJ. 2003 Nov 29;327(7426):1280-2. doi: 10.1136/bmj.327.7426.1280.
Abstract
When mortality from melioidosis fell sharply after multiple changes in management at an Australian hospital, doctors wanted to identify whether a new drug was responsible. But designing a trial that was ethically acceptable proved impossible
摘要
在澳大利亚一家医院对治疗方案进行多次调整后，类鼻疽病的死亡率急剧下降，医生们想确定新药是否起了作用。但事实证明，设计一项符合伦理道德的试验是不可能的。
相似文献
1
Ethical problems of evaluating a new treatment for melioidosis.评估类鼻疽新疗法的伦理问题。
BMJ. 2003 Nov 29;327(7426):1280-2. doi: 10.1136/bmj.327.7426.1280.
2
A randomized controlled trial of granulocyte colony-stimulating factor for the treatment of severe sepsis due to melioidosis in Thailand.在泰国进行的粒细胞集落刺激因子治疗类鼻疽所致严重脓毒症的随机对照试验。
Clin Infect Dis. 2007 Aug 1;45(3):308-14. doi: 10.1086/519261. Epub 2007 Jun 15.
3
Adjunctive granulocyte colony-stimulating factor for treatment of septic shock due to melioidosis.辅助性粒细胞集落刺激因子治疗类鼻疽所致感染性休克
Clin Infect Dis. 2004 Jan 1;38(1):32-7. doi: 10.1086/380456. Epub 2003 Dec 4.
4
Granulocyte colony-stimulating factor in patients with ST segment elevation myocardial infarction: a disappointment-stimulating factor?粒细胞集落刺激因子在 ST 段抬高型心肌梗死患者中的应用：令人失望的刺激因子？
Int J Cardiol. 2010 Nov 5;145(1):138-9. doi: 10.1016/j.ijcard.2009.06.053. Epub 2009 Aug 3.
5
Meta-analysis of randomized controlled trials of granulocyte colony-stimulating factor prophylaxis in adult cancer patients receiving chemotherapy.接受化疗的成年癌症患者预防性使用粒细胞集落刺激因子的随机对照试验的荟萃分析。
Cancer Treat Res. 2011;157:127-43. doi: 10.1007/978-1-4419-7073-2_8.
6
Severe sepsis due to melioidosis.类鼻疽所致严重脓毒症
Chest. 2006 Oct;130(4):1282. doi: 10.1378/chest.130.4.1282.
7
Granulocyte-colony stimulating factor in refractory ischemic heart disease: throwing stones from glass houses.
Am Heart J. 2009 May;157(5):e39; author reply e41. doi: 10.1016/j.ahj.2009.02.009.
8
Granulocyte colony-stimulating factor in afebrile patients with neutropenia.粒细胞集落刺激因子在无发热性中性粒细胞减少症患者中的应用
N Engl J Med. 1997 Oct 30;337(18):1319-20. doi: 10.1056/NEJM199710303371814.
9
Safety and efficacy of granulocyte colony-stimulating factor for patients with recent myocardial infarction: a meta-analysis.粒细胞集落刺激因子对近期心肌梗死患者的安全性和有效性：一项荟萃分析。
Int J Cardiol. 2008 Oct 13;129(3):455-7. doi: 10.1016/j.ijcard.2007.06.067. Epub 2007 Aug 13.
10
The role of granulocyte colony-stimulating factor with dose-intensive chemotherapy.粒细胞集落刺激因子在剂量密集化疗中的作用。
Semin Oncol. 1994 Feb;21(1 Suppl 1):7-9.
引用本文的文献
1
Melioidosis in Thailand: Present and Future.泰国的类鼻疽：现状与未来。
Trop Med Infect Dis. 2018;3(2):38. doi: 10.3390/tropicalmed3020038. Epub 2018 Apr 8.
2
Melioidosis: Clinical impact and public health threat in the tropics.类鼻疽：热带地区的临床影响与公共卫生威胁
PLoS Negl Trop Dis. 2017 May 11;11(5):e0004738. doi: 10.1371/journal.pntd.0004738. eCollection 2017 May.
3
The intellectual challenges and emotional consequences of equipoise contributed to the fragility of recruitment in six randomized controlled trials.均衡状态带来的智力挑战和情绪后果导致了六项随机对照试验中招募的脆弱性。
J Clin Epidemiol. 2014 Aug;67(8):912-20. doi: 10.1016/j.jclinepi.2014.03.010. Epub 2014 May 5.
本文引用的文献
1
G-CSF immunotherapy for treatment of acute disseminated murine melioidosis.粒细胞集落刺激因子免疫疗法治疗急性播散性小鼠类鼻疽病。
FEMS Microbiol Lett. 2003 Jul 29;224(2):315-8. doi: 10.1016/S0378-1097(03)00473-7.
2
Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis.关于使用非格司亭治疗肺炎合并严重脓毒症住院患者的多中心、双盲、安慰剂对照研究。
Crit Care Med. 2003 Feb;31(2):367-73. doi: 10.1097/01.CCM.0000048629.32625.5D.
3
An audit of the use of granulocyte colony-stimulating factor in septic shock.脓毒性休克中粒细胞集落刺激因子使用情况的审计。
Intern Med J. 2002 Apr;32(4):143-8. doi: 10.1046/j.1445-5994.2002.00195.x.
4
Ethics and statistics in randomized clinical trials.随机临床试验中的伦理与统计学
Stat Sci. 1991;6(1):52-88. doi: 10.1214/ss/1177011934.
5
Endemic melioidosis in tropical northern Australia: a 10-year prospective study and review of the literature.澳大利亚北部热带地区的地方性类鼻疽病：一项为期10年的前瞻性研究及文献综述
Clin Infect Dis. 2000 Oct;31(4):981-6. doi: 10.1086/318116. Epub 2000 Oct 25.
6
A randomized controlled trial of filgrastim for the treatment of hospitalized patients with multilobar pneumonia.一项关于非格司亭治疗多叶性肺炎住院患者的随机对照试验。
J Infect Dis. 2000 Sep;182(3):970-3. doi: 10.1086/315775. Epub 2000 Aug 17.
7
Short-course zidovudine for perinatal HIV-1 transmission in Bangkok, Thailand: a randomised controlled trial. Bangkok Collaborative Perinatal HIV Transmission Study Group.泰国曼谷使用齐多夫定短疗程预防围产期HIV-1传播的随机对照试验。曼谷围产期HIV传播协作研究组
Lancet. 1999 Mar 6;353(9155):773-80. doi: 10.1016/s0140-6736(98)10411-7.
8
A randomized controlled trial of filgrastim as an adjunct to antibiotics for treatment of hospitalized patients with community-acquired pneumonia. CAP Study Group.一项关于非格司亭作为抗生素辅助药物治疗社区获得性肺炎住院患者的随机对照试验。社区获得性肺炎研究组。
J Infect Dis. 1998 Oct;178(4):1075-80. doi: 10.1086/515694.
9
When are placebo-controlled trials no longer appropriate?何时安慰剂对照试验不再适用？
Control Clin Trials. 1997 Dec;18(6):602-12; discussion 661-6. doi: 10.1016/s0197-2456(97)00006-8.
10
Filgrastim (r-metHuG-CSF): the first 10 years.非格司亭（重组甲磺酸去铁胺人粒细胞集落刺激因子）：头10年
Blood. 1996 Sep 15;88(6):1907-29.
Zotero 插件