Learning from nature's drug factories: nonribosomal synthesis of macrocyclic peptides.
作者信息
Sieber Stephan A, Marahiel Mohamed A
机构信息
Fachbereich Chemie/Biochemie, Philipps-Universität Marburg, 35032 Marburg, Germany.
出版信息
J Bacteriol. 2003 Dec;185(24):7036-43. doi: 10.1128/JB.185.24.7036-7043.2003.
Abstract
摘要
相似文献
1
Learning from nature's drug factories: nonribosomal synthesis of macrocyclic peptides.向大自然的药物工厂学习：大环肽的非核糖体合成
J Bacteriol. 2003 Dec;185(24):7036-43. doi: 10.1128/JB.185.24.7036-7043.2003.
2
Nucleic acid independent synthesis of peptides.肽的非核酸依赖性合成
Curr Top Microbiol Immunol. 1981;91:129-77. doi: 10.1007/978-3-642-68058-8_6.
3
Biosynthesis: Ringing in a new view.生物合成：开启新视角。
Nat Chem Biol. 2012 May 17;8(6):505-7. doi: 10.1038/nchembio.973.
4
Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics.非核糖体肽合成的分子机制：新型抗生素的研发途径
Chem Rev. 2005 Feb;105(2):715-38. doi: 10.1021/cr0301191.
5
Peptidolactones.肽内酯
Biotechnology. 1995;28:173-96. doi: 10.1016/b978-0-7506-9095-9.50013-7.
6
Engineering Escherichia coli to produce nonribosomal peptide antibiotics.工程改造大肠杆菌以生产非核糖体肽抗生素。
Nat Chem Biol. 2006 Aug;2(8):398-400. doi: 10.1038/nchembio0806-398.
7
Loloatins A-D, cyclic decapeptide antibiotics produced in culture by a tropical marine bacterium.洛洛他汀A-D，由一种热带海洋细菌在培养物中产生的环十肽抗生素。
J Nat Prod. 1999 Jan;62(1):80-5. doi: 10.1021/np980219f.
8
Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines.在非核糖体肽合成酶（NRPS）装配线上，对链延伸期间及之后修饰非核糖体肽的定制酶。
Curr Opin Chem Biol. 2001 Oct;5(5):525-34. doi: 10.1016/s1367-5931(00)00235-0.
9
[Biologically active nonribosomal peptides. I. Nonribosamal polypeptide antibiotics].
Antibiot Khimioter. 2011;56(3-4):57-68.
10
Engineering of novel polyketides. Progress and Prospects.
Ann N Y Acad Sci. 1996 Oct 12;799:32-45. doi: 10.1111/j.1749-6632.1996.tb33174.x.
引用本文的文献
1
Characterization of RufT Thioesterase Domain Reveals Insights into Rufomycin Cyclization and the Biosynthetic Origin of Rufomyazine.RufT硫酯酶结构域的表征揭示了对鲁佛霉素环化及鲁佛米嗪生物合成起源的见解。
ACS Chem Biol. 2025 Mar 21;20(3):573-580. doi: 10.1021/acschembio.4c00802. Epub 2025 Mar 6.
2
Tackling Undruggable Targets with Designer Peptidomimetics and Synthetic Biologics.用设计肽模拟物和合成生物制剂攻克不可成药靶点。
Chem Rev. 2024 Nov 27;124(22):13020-13093. doi: 10.1021/acs.chemrev.4c00423. Epub 2024 Nov 14.
3
Recent advances in microbially derived chlorinated antiparasitic compounds.微生物源氯化抗寄生虫化合物的最新进展。
Mol Divers. 2024 Oct 30. doi: 10.1007/s11030-024-11018-0.
4
Rapid Peptide Cyclization Inspired by the Modular Logic of Nonribosomal Peptide Synthetases.受非核糖体肽合成酶模块化逻辑启发的快速肽环化
J Am Chem Soc. 2024 Jun 6;146(24):16787-801. doi: 10.1021/jacs.4c04711.
5
Training Neural Network Models Using Molecular Dynamics Simulation Results to Efficiently Predict Cyclic Hexapeptide Structural Ensembles.使用分子动力学模拟结果训练神经网络模型，以高效预测环状六肽结构集合。
J Chem Theory Comput. 2023 Jul 25;19(14):4757-4769. doi: 10.1021/acs.jctc.3c00154. Epub 2023 May 26.
6
Chemo-Enzymatic Synthesis of Non-ribosomal Macrolactams by a Penicillin-Binding Protein-Type Thioesterase.利用青霉素结合蛋白型硫酯酶进行非核糖体大环内酰胺的化学酶法合成。
Methods Mol Biol. 2023;2670:127-144. doi: 10.1007/978-1-0716-3214-7_6.
7
Spatial Structure Formation by RsmE-Regulated Extracellular Secretions in Pseudomonas fluorescens Pf0-1.荧光假单胞菌 Pf0-1 中 RsmE 调控的细胞外分泌的空间结构形成。
J Bacteriol. 2022 Oct 18;204(10):e0028522. doi: 10.1128/jb.00285-22. Epub 2022 Sep 27.
8
Do Bacteria Provide an Alternative to Cancer Treatment and What Role Does Lactic Acid Bacteria Play?细菌能否为癌症治疗提供替代方案，乳酸菌又发挥着怎样的作用？
Microorganisms. 2022 Aug 27;10(9):1733. doi: 10.3390/microorganisms10091733.
9
New Tripeptide Derivatives Asperripeptides A-C from Vietnamese Mangrove-Derived Fungus LM.5.2.越南红树林来源真菌 LM.5.2 的新三肽衍生物 Asperripeptides A-C
Mar Drugs. 2022 Jan 17;20(1):77. doi: 10.3390/md20010077.
10
Nerpa: A Tool for Discovering Biosynthetic Gene Clusters of Bacterial Nonribosomal Peptides.Nerpa：一种用于发现细菌非核糖体肽生物合成基因簇的工具。
Metabolites. 2021 Oct 11;11(10):693. doi: 10.3390/metabo11100693.
本文引用的文献
1
Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains.将肽基辅酶A加载到肽基载体蛋白上：一种通过硫酯酶结构域表征大环化的新方法。
J Am Chem Soc. 2003 Sep 10;125(36):10862-6. doi: 10.1021/ja0361852.
2
Structures of naturally occurring circular proteins from bacteria.来自细菌的天然存在的环状蛋白质的结构。
J Bacteriol. 2003 Jul;185(14):4011-21. doi: 10.1128/JB.185.14.4011-4021.2003.
3
Nonribosomal peptides: from genes to products.非核糖体肽：从基因到产物
Nat Prod Rep. 2003 Jun;20(3):275-87. doi: 10.1039/b111145k.
4
The sypA, sypS, and sypC synthetase genes encode twenty-two modules involved in the nonribosomal peptide synthesis of syringopeptin by Pseudomonas syringae pv. syringae B301D.sypA、sypS和sypC合成酶基因编码22个模块，这些模块参与丁香假单胞菌丁香致病变种B301D的丁香肽素的非核糖体肽合成。
Mol Plant Microbe Interact. 2003 Apr;16(4):271-80. doi: 10.1094/MPMI.2003.16.4.271.
5
Vancomycin assembly: nature's way.万古霉素的合成：自然之道。
Angew Chem Int Ed Engl. 2003 Feb 17;42(7):730-65. doi: 10.1002/anie.200390202.
6
Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase.将表面活性素合成酶C末端硫酯酶结构域鉴定为环脂肽合成酶。
Biochemistry. 2002 Nov 12;41(45):13350-9. doi: 10.1021/bi026592a.
7
Ways of assembling complex natural products on modular nonribosomal peptide synthetases.在模块化非核糖体肽合成酶上组装复杂天然产物的方法。
Chembiochem. 2002 Jun 3;3(6):490-504. doi: 10.1002/1439-7633(20020603)3:6<490::AID-CBIC490>3.0.CO;2-N.
8
Synthesis of tyrocidine A and its analogues by spontaneous cyclization in aqueous solution.
Org Lett. 2002 Aug 22;4(17):2893-5. doi: 10.1021/ol0263191.
9
Biomimetic synthesis and optimization of cyclic peptide antibiotics.环肽抗生素的仿生合成与优化
Nature. 2002 Aug 8;418(6898):658-61. doi: 10.1038/nature00907.
10
The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains.VibH的结构代表非核糖体肽合成酶的缩合、环化和差向异构化结构域。
Nat Struct Biol. 2002 Jul;9(7):522-6. doi: 10.1038/nsb810.
Zotero 插件