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南非钩麻抑制成纤维细胞系L929中脂多糖刺激的环氧化酶-2和诱导型一氧化氮合酶的表达。

Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric oxide synthase in fibroblast cell line L929.

作者信息

Jang Mi-Hyeon, Lim Sabina, Han Seung-Moo, Park Hi-Joon, Shin Insop, Kim Jin-Woo, Kim Nam-Jae, Lee Ji-Suk, Kim Kyung-Ah, Kim Chang-Ju

机构信息

Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.

出版信息

J Pharmacol Sci. 2003 Nov;93(3):367-71. doi: 10.1254/jphs.93.367.

DOI:10.1254/jphs.93.367
PMID:14646256
Abstract

Harpagophytum procumbens (Pedaliaceae) has been used for the treatment of pain and arthritis. The effect of Harpagophytum procumbens against lipopolysaccharide-induced inflammation was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, reverse transcription-polymerase chain reaction, prostaglandin E(2) (PGE(2)) immunoassay, and nitric oxide detection on mouse fibroblast cell line L929. The aqueous extract of Harpagophytum procumbens was shown to suppress PGE(2) synthesis and nitric oxide production by inhibiting lipopolysaccharide-stimulated enhancement of the cyclooxygenase-2 and inducible nitric oxide synthase (iNOS) mRNAs expressions in L929 cells. These results suggest that Harpagophytum procumbens exerts anti-inflammatory and analgesic effects probably by suppressing cyclooxygenase-2 and iNOS expressions.

摘要

南非钩麻（胡麻科）已被用于治疗疼痛和关节炎。使用3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四氮唑溴盐法、逆转录-聚合酶链反应、前列腺素E2（PGE2）免疫测定法以及对小鼠成纤维细胞系L929进行一氧化氮检测，研究了南非钩麻对脂多糖诱导的炎症的影响。结果表明，南非钩麻水提取物通过抑制脂多糖刺激的L929细胞中环氧合酶-2和诱导型一氧化氮合酶（iNOS）mRNA表达增强，从而抑制PGE2合成和一氧化氮生成。这些结果提示，南非钩麻可能通过抑制环氧合酶-2和iNOS表达发挥抗炎和镇痛作用。

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