Rao Yerra Koteswara, Damu Amooru Gangaiah, Rao Alahari Janardhan, Venkatesan Shanmuganathan, Kuo Ping-Chung, Rao Chunduri Venkata, Wu Tian-Shung
Natural Products Division, Department of Chemistry, Sri Venkateswara University, Tirupati, India.
Chem Pharm Bull (Tokyo). 2003 Dec;51(12):1374-6. doi: 10.1248/cpb.51.1374.
Phytochemical investigation of the whole plant of Andrographis viscosula has led to the isolation of three new 2'-oxygenated flavonoids, (2R)-5-hydroxy-7,2',3'-trimethoxyflavanone (1), 7,2',5'-trimethoxyflavone (2), 5,7,2',3'-tetramethoxyflavone (3), and eight known flavones, 5,7,2'-trimethoxyflavone (4), 5,7,2',4',5'-pentamethoxyflavone (5), echioidinin (6), 5,2',6'-trihydroxy-7-methoxyflavone (7), 5-hydroxy-7,2'-dimethoxyflavone (8), echioidin (9), echioidinin 5-O-glucoside (10), and 5,2',6'-trihydroxy-7-methoxyflavone 2'-O-glucoside (11). The structures of 1-11 were elucidated by physical and spectral methods, including extensive 2D NMR studies. The presence of 2'-oxygenated flavonoids is apparently restricted to Andrographis species in Acanthaceae. Therefore, 2'-oxygenated flavonoids are regarded as chemotaxonomic markers of Andrographis genus in the Acanthaceae family.
对黏毛穿心莲全株进行植物化学研究，已分离出三种新的2'-氧化黄酮类化合物，即(2R)-5-羟基-7,2',3'-三甲氧基黄烷酮(1)、7,2',5'-三甲氧基黄酮(2)、5,7,2',3'-四甲氧基黄酮(3)，以及八种已知黄酮，即5,7,2'-三甲氧基黄酮(4)、5,7,2',4',5'-五甲氧基黄酮(5)、紫锥菊素(6)、5,2',6'-三羟基-7-甲氧基黄酮(7)、5-羟基-7,2'-二甲氧基黄酮(8)、紫锥菊定(9)、紫锥菊素5-O-葡萄糖苷(10)和5,2',6'-三羟基-7-甲氧基黄酮2'-O-葡萄糖苷(11)。通过物理和光谱方法，包括广泛的二维核磁共振研究，阐明了1-11的结构。2'-氧化黄酮类化合物的存在显然仅限于爵床科穿心莲属植物。因此，2'-氧化黄酮类化合物被视为爵床科穿心莲属的化学分类学标记。
