Shen De-Yang, Juang Shin-Hun, Kuo Ping-Chung, Huang Guan-Jhong, Chan Yu-Yi, Damu Amooru G, Wu Tian-Shung
Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan.
Int J Mol Sci. 2012 Dec 27;14(1):496-514. doi: 10.3390/ijms14010496.
Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2'-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (1-2) and (6-19) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed.
对穿心莲全草进行植物化学研究，得到了两种新的2'-氧化黄酮类化合物（1）和（2）、两种新的苯基糖苷（3）和（4），以及37个已知结构的化合物。通过光谱分析和化学转化研究阐明了新化合物的结构。在分离得到的化合物中，对（1-2）和（6-19）进行了诱导型一氧化氮合酶（iNOS）抑制生物活性检测。还讨论了黄酮类化合物抑制一氧化氮（NO）生成的构效关系。
Zotero 插件
