Rochard E, Barthes D, Courtois P
Institut du Médicament, Faculté de Médecine et de Pharmacie, Poitiers, France.
J Clin Pharm Ther. 1992 Oct;17(5):315-8. doi: 10.1111/j.1365-2710.1992.tb01310.x.
The stability of cisplatin in admixture stored in portable pump reservoirs was investigated. Admixtures containing 0.9 or 0.5 mg/ml cisplatin in 0.9% sodium chloride injection were placed in 80-ml ethylene vinylacetate (EVA) drug reservoirs protected from light and 1-ml quantities were withdrawn immediately after preparation and after storage for 1, 2, 3, 4, 7, 14, 28 days at +22 or +35 degrees C. Three samples for each condition from each admixture were tested for drug concentration using a stability-indicating high-performance liquid chromatographic method. No colour change or precipitation was observed, and pH values were stable for the duration of the study. Loss of water through the reservoirs was substantial only when stored at +35 degrees C for 28 days. Cisplatin is stable in the infusion fluid used for 28 days under all the storage conditions considered.
研究了顺铂在便携式泵储液器中混合液的稳定性。将含0.9%氯化钠注射液中0.9或0.5mg/ml顺铂的混合液置于80ml避光的乙烯-醋酸乙烯酯（EVA）药物储液器中，制备后及在+22或+35℃储存1、2、3、4、7、14、28天后立即取出1ml量的混合液。每种混合液在每种条件下取三个样品，使用稳定性指示高效液相色谱法检测药物浓度。未观察到颜色变化或沉淀，且在研究期间pH值稳定。仅在+35℃储存28天时，储液器中的水分损失较大。在所考虑的所有储存条件下，顺铂在输注液中28天内都是稳定的。
