Deshmukh M
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110-1031, USA.
Apoptosis. 1998 Dec;3(6):387-94. doi: 10.1023/a:1009602401251.
The importance of caspases in developmental neuronal death is well-established. Recent data provide compelling evidence of caspase activation after ischaemic brain injury. Caspase inhibitors reduce cell death in several models of ischaemic injury. This review summarizes our current understanding of caspase function in ischaemic brain injury and examines the accumulating evidence of caspase participation in several neurodegenerative diseases. The therapeutic consequences of caspase inhibitor treatment in reducing cell death after such injury are also discussed.
半胱天冬酶在发育性神经元死亡中的重要性已得到充分证实。最近的数据为缺血性脑损伤后半胱天冬酶的激活提供了令人信服的证据。在几种缺血性损伤模型中，半胱天冬酶抑制剂可减少细胞死亡。本综述总结了我们目前对缺血性脑损伤中半胱天冬酶功能的理解，并探讨了半胱天冬酶参与几种神经退行性疾病的越来越多的证据。还讨论了半胱天冬酶抑制剂治疗在减少此类损伤后细胞死亡方面的治疗效果。
