Rubio C A
Gastrointestinal and Liver Pathology Research Lab, Department of Pathology, Karolinska Institute, Stockholm, Sweden.
Apoptosis. 1997;2(6):489-93. doi: 10.1023/a:1026430313275.
Intraepithelial lymphocytes (IELs) and Intraepithelial apoptotic granules (AGs) are found in the vast majority of colorectal adenomas, less frequently in incipient carcinomas and occasionally in advanced colorectal carcinomas. In colorectal adenomas, the activated and cytotoxic IELs undergo apoptosis by a Fas-FasL mechanism. In advanced invasive carcinomas lacking IELs, that mechanism cannot be activated. On the other hand, the peritumoural lymphocytes which surround some advanced invasive carcinomas may abrogate to-be-metastatic tumor cells, as treated cancer patients with peritumoural lymphocytes have a better 5-years' survival than those without that peritumoural barrier. In colorectal adenomas the host reaction (IELs) dysplastic cells Fas-dependent confrontation seems to prevent rapidly proliferating adenomas from becoming rapidly invasive carcinomas, since that process takes 10 to 20 years to evolve.
上皮内淋巴细胞（IELs）和上皮内凋亡颗粒（AGs）在绝大多数结直肠腺瘤中均可发现，在早期癌中较少见，而在晚期结直肠癌中偶尔可见。在结直肠腺瘤中，活化的细胞毒性IELs通过Fas-FasL机制发生凋亡。在缺乏IELs的晚期浸润癌中，该机制无法被激活。另一方面，一些晚期浸润癌周围的肿瘤周淋巴细胞可能会消除即将转移的肿瘤细胞，因为有肿瘤周淋巴细胞的癌症患者5年生存率高于没有这种肿瘤周屏障的患者。在结直肠腺瘤中，宿主反应（IELs）与发育异常细胞的Fas依赖性对抗似乎可阻止快速增殖的腺瘤迅速转变为浸润癌，因为这一过程需要10至20年才能演变完成。
