Sato M, Harada K, Yura Y, Bando T, Azuma M, Kawamata H, Iga H, Yoshida H
Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, 3 Kuramoto-cho, Tokushima Japan.
Apoptosis. 1997;2(1):106-13. doi: 10.1023/a:1026400111941.
A patient with locally-advanced submandibular adenoid cystic carcinoma with poorly differentiated solid type, was treated with differentiation-inducing agent, vesnarinone, per os at a dose of 60 mg/day daily for 8 weeks. The vesnarinone administration caused marked regression of the tumour. In addition to conversion into the well-differentiated tubular type from the poorly differentiated solid type, the induction of apoptosis and LeY antigen was observed in the treated tumour. These findings indicate that vesnarinone might be a useful therapeutic agent for treatment of salivary cancer. Since we found the new expression of LeY antigen in the well-differentiated tubular lesion in the salivary adenoid cystic carcinoma treated with vesnarinone, we examined the LeY antigen expression in relation to tumour differentiation in five cases of salivary adenoid cystic carcinoma. Consequently, tissue sections from all of the adenoid cystic carcinoma examined showed no positive LeY staining, except for some areas in the tumour lesion with the tubular pattern including the histologically normal-appearing tissue adjacent to the tumour tissue. These findings suggest that there is the intimate relationship between the LeY antigen expression and tumour differentiation in human salivary adenoid cystic carcinoma.
一名患有局部晚期下颌下腺样囊性癌且为低分化实体型的患者，口服分化诱导剂维司力农，剂量为每日60毫克，持续8周。维司力农的给药使肿瘤明显消退。除了肿瘤从低分化实体型转变为高分化管状型外，在接受治疗的肿瘤中还观察到了凋亡和LeY抗原的诱导。这些发现表明维司力农可能是治疗唾液腺癌的一种有用的治疗药物。由于我们在接受维司力农治疗的唾液腺样囊性癌的高分化管状病变中发现了LeY抗原的新表达，我们检查了5例唾液腺样囊性癌中LeY抗原表达与肿瘤分化的关系。结果，除了肿瘤病变中具有管状模式的一些区域，包括与肿瘤组织相邻的组织学上外观正常的组织外，所有检查的腺样囊性癌组织切片均未显示LeY染色阳性。这些发现表明，在人类唾液腺样囊性癌中，LeY抗原表达与肿瘤分化之间存在密切关系。
